Ford AT, LeBlanc GA (2020) Endocrine disruption in invertebrates: a survey of research progress. Environ Sci Technol 54:13365–13369
Article
CAS
Google Scholar
Chapman AD (2009) Numbers of living species in Australia and the World, 2nd edition. Report for the Australian Biological Resources Study, Canberra, Australia September 2009.
deFur PL (2004) Use and role of invertebrate models in endocrine disruptor research and testing. ILAR J 45:484–493
Article
CAS
Google Scholar
European Commission (EC) (2012) LIFE and invertebrate conservation. Publications Office of the European Union, Luxembourg
Google Scholar
Collen B, Böhm M, Kemp R, Baillie JEM (2012) Spineless: status and trends of the world’s invertebrates. Zoological Society of London, London
Google Scholar
Langston W (2020) Endocrine disruption and altered sexual development in aquatic organisms: an invertebrate perspective. J Mar Biol Assoc UK 100:495–515
Article
Google Scholar
deFur PL, Crane M, Ingersoll C, Tattersfield L (eds) (1999) Endocrine disruption in invertebrates: endocrinology, testing, and assessment. SETAC Press, Pensacola, FL
Google Scholar
Weltje L, Schulte-Oehlmann U (2007) The seven-year itch—progress in research in research on endocrine disruption in aquatic invertebrates since 1999. Ecotoxicology 16:1–3
Article
Google Scholar
Dhadialla TS (ed) (2012) Insect growth disruptors. Adv Insect Physiol 43:1-552
Jindra M (2021) New ways and new hopes for IGR development. J Pestic Sci 46:3–6
Article
CAS
Google Scholar
Jindra M, Bittova L (2020) The juvenile hormone receptor as a target of juvenoid “insect growth regulators.” Arch Insect Biochem Physiol 103(3):e21615
Article
CAS
Google Scholar
Billas IML, Browning C, Lawrence MC, Graham LD, Moras D, Hill RJ (2009) The structure and function of ecdysone receptors. In: Smagghe G (ed) Ecdysone: structures and functions. Springer, Dordrecht
Google Scholar
Smagghe G (2008) Ecdysone agonists, a novel group of insect growth regulators. In: Capinera JL (ed) Encyclopedia of entomology. Springer, Dordrecht
Google Scholar
Lagadic L, Katsiadaki I, Biever R, Guiney PD, Karouna-Renier N, Schwarz T, Meador JP (2017) Tributyltin: advancing the science on assessing endocrine disruption with an unconventional endocrine-disrupting compound. In: de Voogt P (ed) Reviews of environmental contamination and toxicology 245. Springer, Cham, pp 65–127
Chapter
Google Scholar
Matthiessen P, Wheeler JR, Weltje L (2018) A review of the evidence for endocrine disrupting effects of current-use chemicals on wildlife populations. Crit Rev Toxicol 48:195–216
Article
CAS
Google Scholar
Cuvillier-Hot V, Lenoir A (2020) Invertebrates facing contamination by endocrine disruptors: novel evidences and recent insights. Mol Cell Endocrinology 504:110712
Article
CAS
Google Scholar
Hallmann CA, Sorg M, Jongejans E, Siepel H, Hofland N, Schwan H, Stenmans W, Müller A, Sumser H, Hörren T, Goulson D, de Kroon H (2017) More than 75 percent decline over 27 years in total flying insect biomass in protected areas. PLoS ONE 12(10):e0185809
Article
CAS
Google Scholar
Hayhow DB, Eaton MA, Stanbury AJ, Burns F, Kirby WB, Bailey, Beckmann B, Bedford J, Boersch-Supan PH, Coomber F, Dennis EB, Dolman SJ, Dunn E, Hall J, Harrower C, Hatfield JH, Hawley J, Haysom K, Hughes J, Johns DG, Mathews F, McQuatters-Gollop A, Noble DG, Outhwaite CL, Pearce-Higgins JW, Pescott OL, Powney GD, Symes N (2019) State of nature 2019. State of Nature Partnership (UK), 107pp.
Godfray HCJ, Stephens AEA, Jepson PD, Jobling S, Johnson AC, Matthiessen P, Sumpter JP, Tyler CR, McLean AR (2019) A restatement of the natural science evidence base on the effects of endocrine disrupting chemicals on wildlife. Proc R Soc B 286:20182416
Article
CAS
Google Scholar
LaFont R (2000) The endocrinology of invertebrates. Ecotoxicology 9:41–57
Article
CAS
Google Scholar
European Commission (EC) (2018a) Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions. Towards a comprehensive European Union framework on endocrine disruptors. European Commission, Brussels, Belgium, 7.11.2018 COM(2018) 734 final.
World Health Organization International Programme on Chemical Safety (WHO-IPCS) (2002) Global assessment of the state-of-the-science of endocrine disruptors. World Health Organization, Geneva
Google Scholar
Matthiessen PG (2013) Ecotoxicity test methods for endocrine-disrupting chemicals: an introduction. In: Matthiessen PG (ed) Endocrine disrupters: hazard testing and assessment methods. Wiley, Hoboken, NJ, pp 1–6
Chapter
Google Scholar
Soin T, Smagghe G (2007) Endocrine disruption in aquatic insects: a review. Ecotoxicology 16:83–93
Article
CAS
Google Scholar
Knigge T, LeBlanc GA, Ford AT (2021) A crab is not a fish: unique aspects of the crustacean endocrine system and considerations for endocrine toxicology. Front Endocrinol 12:587608
Article
Google Scholar
Kusk KO, Wollenberger L (2007) Towards an internationally harmonized test method for reproductive and developmental effects of endocrine disrupters in marine copepods. Ecotoxicology 16:183–195
Article
CAS
Google Scholar
LeBlanc GA (2007) Crustacean endocrine toxicology: a review. Ecotoxicology 16:61–81
Article
CAS
Google Scholar
Toyota K, Miyakawa H, Hiruta C, Sato T, Katayama H, Ohira T, Iguchi T (2021) Sex determination and differentiation in decapod and cladoceran crustaceans: an overview of endocrine regulation. Genes (Basel) 12:305
Article
CAS
Google Scholar
Matthiessen P (2008) An assessment of endocrine disruption in mollusks and the potential for developing internationally standardized mollusk life cycle test guidelines. Integr Environ Assess Manag 4:274–284
Article
CAS
Google Scholar
Lagadic L, Coutellec M-A, Caquet T (2007) Endocrine disruption in aquatic pulmonated molluscs: few evidences, many challenges. Ecotoxicology 16:45–59
Article
CAS
Google Scholar
Huang W, Xu F, Qu T, Zhang R, Li L, Que H, Zhang G (2015) Identification of thyroid hormones and functional characterization of thyroid hormone receptor in the pacific oyster Crassostrea gigas provide insight into evolution of the thyroid hormone system. PLoS ONE 10(12):e0144991
Article
CAS
Google Scholar
Wang G, Zhang L, Xu J, Yin C, Zhang Z, Wang Y (2019) The roles of thyroid hormone receptor and T3 in metamorphosis of Haliotis diversicolor. J Oceanol Limnol 37:745–758
Article
CAS
Google Scholar
Lustrino D, Silva ACM, Araujo IG, Tunholi VM, Tunholi-Alves VM, Castro RN, Carvalho DP, Pinheiro J, Marassi MP (2017) Evidence of the presence of thyroid hormones in Achatina fulica snails. An Acad Bras Cienc 89(3 Suppl):2181–2188
Article
CAS
Google Scholar
Dumollard R, Gazo I, Gomes IDL, Besnardeau L, McDougall A (2017) Ascidians: an emerging marine model for drug discovery and screening. Curr Top Med Chem 17:2056–2066
Article
CAS
Google Scholar
Oetken M, Bachmann J, Schulte-Oehlmann U, Oehlmann J (2004) Evidence for endocrine disruption in invertebrates. Internat Rev Cytol 236:1–43
Article
CAS
Google Scholar
Salzet M (2001) The neuroendocrine system of annelids. Can J Zool 79:175–191
Article
CAS
Google Scholar
Sugni M, Mozzi D, Barbaglio A, Bonasoro F, Carnevali MDC (2007) Endocrine disrupting compounds and echinoderms: new ecotoxicological sentinels for the marine ecosystem. Ecotoxicology 16:95–108
Article
CAS
Google Scholar
Takahashi T (2020) Comparative aspects of structure and function of cnidarian neuropeptides. Front Endocrinol 11:339
Article
Google Scholar
Tarrant AM (2007) Hormonal signaling in cnidarians: do we understand the pathways well enough to know whether they are being disrupted? Ecotoxicology 16:5–13
Article
CAS
Google Scholar
Scott AP (2012) Do mollusks use vertebrate sex steroids as reproductive hormones? I: critical appraisal of the evidence for the presence, biosynthesis and uptake of steroids. Steroids 77:1450–1468
Article
CAS
Google Scholar
Scott AP (2013) Do mollusks use vertebrate sex steroids as reproductive hormones? II. Critical review of the evidence that steroids have biological effects. Steroids 78:268–281
Article
CAS
Google Scholar
European Chemicals Agency, European Food Safety Authority [with the technical support of the Joint Research Centre (JRC)] (ECHA/EFSA) (2018) Guidance for the identification of endocrine disruptors in the context of Regulations (EU)No528/2012 and (EC)No1107/2009. EFSA J 16(6):5311
Google Scholar
Crane M, Hallmark N, Lagadic L, Ott K, Pickford D, Preuss T, Thompson H, Thorbek P, Weltje L, Wheeler JR (2019) Establishing the relevance of endocrine-disrupting effects for nontarget vertebrate populations. Integr Environ Assess Manag 15:299–301
Article
Google Scholar
European Commission (EC) (2018b) Setting priorities for further development and validation of test methods and testing approaches for evaluating endocrine disruptors. Final Report. Luxembourg.
European Commission (EC) (2000) Communication from the Commission on the precautionary principle. Commission of the European Communities, Brussels, Belgium, 2.2.2000 COM(2000) 1 final.
European Commission (EC) (2018c) Commission Regulation (EU) 2018/605 of 19 April 2018 amending Annex II to Regulation (EC) No 1107/2009 by setting out scientific criteria for the determination of endocrine disrupting properties. OJ L 101/33. 2018 Apr 20.
European Commission (EC) (2009) Regulation (EC) No 1107/2009 of the European Parliament and of the Council of 21 October 2009 concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC. Official Journal of the European Union 24.11.2009 L 309/1.
European Commission (EC) (2013a) Regulation (EU) No 283/2013 of 1 March 2013 setting out the data requirements for active substances, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market. Official Journal of the European Union 3.4.2013 L 93/1.
European Commission (EC) (2013b) Regulation (EU) No 284/2013 of 1 March 2013 setting out the data requirements for plant protection products, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market. Official Journal of the European Union 3.4.2013 L 93/85.
European Food Safety Authority (EFSA) (2019) Conclusion on the peer review of the pesticide risk assessment of the active substance pyriproxyfen. EFSA J 17:5732
Google Scholar
Autrup H, Barile FA, Blaauboer BJ, Degen GH, Dekant W, Dietrich D, Domingo JL, Batta Gori G, Greim H, Hengstler JG, Kacew S, Marquardt H, Pelkonen O, Savolainen K, Vermeulen NP (2015) Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system. Toxicol Sci. https://doi.org/10.1093/toxsci/kfv082
Article
Google Scholar
Bergman Å, Andersson A-M, Becher G, van den Berg M, Blumberg B, Bjerregaard P, Bornehag C-G, Bornman R, Brandt I, Brian JV, Casey SC, Fowler PA, Frouin H, Giudice LC, Iguchi T, Hass U, Jobling S, Juul A, Kidd KA, Kortenkamp A, Lind M, Martin OV, Muir D, Ochieng R, Olea N, Norrgren L, Ropstad E, Ross PS, Rudén C, Scheringer M, Skakkebaek NE, Söder O, Sonnenschein C, Soto A, Swan S, Toppari J, Tyler CR, Vandenberg LN, Vinggaard AM, Wiberg K, Zoeller RT (2013) Science and policy on endocrine disrupters must not be mixed: a reply to a “common sense” intervention by toxicology journal editors. Environ Health 12:69
Article
Google Scholar
Crane M, Hallmark N, Lagadic L, Ott K, Pickford D, Preuss T, Thompson H, Thorbek P, Weltje L, Wheeler JR (2019) Assessing the population relevance of endocrine-disrupting effects for nontarget vertebrates exposed to plant protection products. Integrr Environ Assess Manag 15:278–291
Article
Google Scholar
Dietrich DR, von Aulock S, Marquardt H, Blaauboer B, Dekant W, Kehrer J, Hengstler J, Collier A, Batta Gori G, Pelkonen O, Lang F, Barile FA, Nijkamp FP, Stemmer K, Li A, Savolainen K, Hayes AW, Gooderham N, Harvey A (2013) Scientifically unfounded precaution drives European Commission’s recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles. Chem Biol Interact 205(1):A1-5
Article
CAS
Google Scholar
Matthiessen PG, Ankley R, Biever P, Bjerregaard C, Borgert K, Brugger A, Blankinship J, Chambers K, Coady L, Constantine Z, Dang Z, Denslow ND, Dreier DA, Dungey S, Gray LE, Gross M, Guiney PD, Hecker M, Holbech H, Iguchi T, Kadlec S, Karouna-Renier NK, Katsiadaki I, Kawashima Y, Kloas W, Krueger H, Kumar A, Lagadic L, Leopold A, Levine SL, Maack G, Marty S, Meador J, Mihaich E, Odum J, Ortego L, Parrott J, Pickford D, Roberts M, Schaefers C, Schwarz T, Solomon K, Verslycke T, Weltje L, Wheeler JR, Williams M, Wolf JC, Yamazaki K (2017) Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances. Integr Environ Assess Manag 13:267–269
Article
CAS
Google Scholar
Solecki R, Kortenkamp A, Bergman A, Chahoud I, Degen GH, Dietrich D, Greim H, Håkansson H, Hass U, Husoy T, Jacobs M, Jobling S, Mantovani A, Marx-Stoelting P, Piersma A, Ritz V, Slama R, Stahlmann R, van den Berg M, Zoeller RT, Boobis AR (2017) Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement. Arch Toxicol 91:1001–1006
Article
CAS
Google Scholar
Zoeller RT, Bergman A, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari J, Vandenberg LN (2014) A path forward in the debate over health impacts of endocrine disrupting chemicals. Environl Health 13:118
Article
CAS
Google Scholar
Organization for Economic Cooperation and Development (OECD) (2018a) Revised Guidance document 150 on standardised test guidelines for evaluating chemicals for endocrine disruption. OECD Series on Testing and Assessment, Paris, France.
Coady KK, Biever RC, Denslow ND, Gross M, Guiney PD, Holbech H, Karouna-Renier NK, Katsiadaki I, Krueger H, Levine SL, Maack G, Williams M, Wolf JC, Ankley GT (2017) Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances. Integr Environ Assess Manag 13:302–316
Article
CAS
Google Scholar
European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) (2016) Guidance on Assessment and Application of Adverse Outcome Pathways (AOPs) Relevant to the Endocrine System, Technical Report No. 128, Brussels, December 2016.
Cherbas L, Koehler MMD, Cherbas P (1989) Effects of juvenile hormone on the ecdysone response of Drosophila Kc cells. Dev Genetics 10:177–188
Article
CAS
Google Scholar
Dinan L, Bourne P, Whiting P, Dhadialla TS, Hutchinson TH (2001) Screening of environmental contaminants for ecdysteroid agonist and antagonist activity using the Drosophila melanogaster B-II cell in vitro assay. Environ Toxicol Chem 20:2038–2046
Article
CAS
Google Scholar
Miyakawa H, Iguchi T (2017) Comparative luciferase assay for establishing reliable in vitro screening system of juvenile hormone agonists. J Appl Toxicol 37:1082–1090
Article
CAS
Google Scholar
Smagghe G, Braeckman BP, Huys N, Raes H (2003) Cultured mosquito cells Aedes albopictus C6/36 (Dip, Culicidae) responsive to 20-hydroxyecdysone and non-steroidal ecdysone antagonists. J Appl Entomol 127:167–173
Article
CAS
Google Scholar
Swevers L, Kravariti L, Ciolfi S, Xenou-Kokoletsi M, Ragoussis N, Smagghe G, Nakagawa Y, Mazomenos B, Iatrou K (2003) A high-throughput screening system for fast detection of ecdysteroid mimetic and antagonistic substances using transformed Bombyx mori derived cell lines. FASEB J 18:134–136
Article
CAS
Google Scholar
Hartung T, De Vries R, Hoffmann S, Hogberg HT, Smirnova L, Tsaioun K, Whaley P, Leist M (2019) Toward good in vitro reporting standards. Altex 36:3–17
Article
Google Scholar
Organization for Economic Cooperation and Development (OECD) (2018c) Guidance document on good in vitro method practices (GIVIMP), OECD Series on Testing and Assessment, No. 286. OECD Publishing, Paris, France.
Browne P, Van Der Wal L, Gourmelon A (2020) OECD approaches and considerations for regulatory evaluation of endocrine disruptors. Mol Cell Endocrinol 504:110675
Article
CAS
Google Scholar
Derwent Innovation (2021) https://clarivate.com/derwent/solutions/derwent-innovation/. Accessed Mar 2021.
Pener MP, Dhadialla TS (2012) Chapter one—an overview of insect growth disruptors; applied aspects. Adv Insect Physiol 43:1–162
Article
Google Scholar
Weltje L (2013) Techniques for measuring endocrine disruption in insects. In: Matthiessen P (ed) Endocrine disrupters: hazard testing and assessment methods. Wiley, Hoboken, NJ, pp 100–115
Chapter
Google Scholar
Breitholtz M (2013) Crustaceans. In: Matthiessen P (ed) Endocrine Disrupters: hazard testing and assessment methods. Wiley, Hoboken, NJ, pp 116–142
Chapter
Google Scholar
Tatarazako N, Oda S (2007) The water flea Daphnia magna (Crustacea, Cladocera) as a test species for screening and evaluation of chemicals with endocrine disrupting effects on crustaceans. Ecotoxicology 16:197–203
Article
CAS
Google Scholar
Verslycke T, Ghekiere A, Raimondo S, Janssen C (2007) Mysid crustaceans as standard models for the screening and testing of endocrine-disrupting chemicals. Ecotoxicology 16:205–219
Article
CAS
Google Scholar
Duft M, Schmitt C, Bachmann J, Brandelik C, Schulte-Oehlmann U, Oehlmann J (2007) Prosobranch snails as test organisms for the assessment of endocrine active chemicals - an overview and a guideline proposal for a reproduction test with the freshwater mudsnail Potamopyrgus antipodarum. Ecotoxicology 16:169–182
Article
CAS
Google Scholar
Janer G, Porte C (2007) Sex steroids and potential mechanisms of non-genomic endocrine disruption in invertebrates. Ecotoxicology 16:145–160
Article
CAS
Google Scholar
McClellan-Green PD (2013) Endocrine disruption in molluscs: processes and testing. In: Matthiessen P (ed) Endocrine disrupters: hazard testing and assessment methods. Wiley, Hoboken, NJ, pp 143–184
Chapter
Google Scholar
Oehlmann J, Di Benedetto P, Tillmann M, Duft M, Oetken M, Schulte-Oehlmann U (2007) Endocrine disruption in prosobranch molluscs: evidence and ecological relevance. Ecotoxicology 16:29–43
Article
CAS
Google Scholar
Höss S, Weltje L (2007) Endocrine disruption in nematodes: effects and mechanisms. Ecotoxicology 16:15–28
Article
CAS
Google Scholar
Hutchinson TH (2007) Small is useful in endocrine disrupter assessment—four key recommendations for aquatic invertebrate research. Ecotoxicology 16:231–238
Article
CAS
Google Scholar
European Food Safety Authority Scientific Committee (EFSA SC) (2013) Scientific Opinion on the hazard assessment of endocrine disruptors: scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment. EFSA J 11:3132
Google Scholar
Munn S, Goumenou M (2013) Key scientific issues relevant to the identification and characterisation of endocrine disrupting substances. Report of the Endocrine Disrupters Expert Advisory Group. European Commission Joint Research Centre, Institute for Health and Consumer Protection, Ispra (VA), Italy
Hannas BR, Wang YH, Thomson S, Kwon G, Li H, LeBlanc GA (2011) Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna). Aquat Toxicol 101:351–357
Article
CAS
Google Scholar
Morthorst JE, Holbech H, Jeppesen M, Kinnberg KL, Pedersen KL, Bjerregaard P (2014) Evaluation of yolk protein levels as estrogenic biomarker in bivalves; comparison of the alkali-labile phosphate method (ALP) and a species-specific immunoassay (ELISA). Comp Biochem Physiol C Toxicol Pharmacol 166:88–95
Article
CAS
Google Scholar
Short SJ, Yang G, Kille P, Ford AT (2014) Vitellogenin is not an appropriate biomarker of feminisation in a crustacean. Aquat Toxicol 153:89–97
Article
CAS
Google Scholar
Fernández-González LE, Diz AP, Grueiro NG, Muniategui-Lorenzo S, Beiras R, Sánchez-Marín P (2020) No evidence that vitellogenin protein expression is induced in marine mussels after exposure to an estrogenic chemical. Sci Total Environ 721:137638
Article
CAS
Google Scholar
Fodor I, Urbán P, Scott AP, Pirger Z (2020) A critical evaluation of some of the recent so-called ‘evidence’ for the involvement of vertebrate-type sex steroids in the reproduction of mollusks. Mol Cell Endocrinol 516:110949
Article
CAS
Google Scholar
Scott AP (2018) Is there any value in measuring vertebrate steroids in invertebrates? Gen Comp Endocrinol 265:77–82
Article
CAS
Google Scholar
Balbi T, Ciacci C, Canesi L (2019) Estrogenic compounds as exogenous modulators of physiological functions in molluscs: signaling pathways and biological responses. Comp Biochem Physiol Part C 222:135–144
CAS
Google Scholar
Fernandes D, Loi B, Porte C (2011) Biosynthesis and metabolism of steroids in molluscs. J Steroid Biochem Mol Biol 127:189–195
Article
CAS
Google Scholar
Köhler H-R, Kloas W, Schirling M, Lutz I, Reye AL, Langen J-S, Triebskorn R, Nagel R, Schönfelder G (2007) Sex steroid receptor evolution and signalling in aquatic invertebrates. Ecotoxicology 16:131–143
Article
CAS
Google Scholar
Tran TKA, Yu RMK, Islam R, Nguyen THT, Bui TLH, Kong RYC, O’Connor WA, Leusch FDL, Andrew-Priestley M, MacFarlane GR (2019) The utility of vitellogenin as a biomarker of estrogenic endocrine disrupting chemicals in molluscs. Environ Pollut 248:1067e1078
Article
CAS
Google Scholar
Sainath SB, André A, Castro LFC, Santos MM (2019) The evolutionary road to invertebrate thyroid hormone signaling: Perspectives for endocrine disruption processes. Comp Biochem Physiol C 223:124–138
CAS
Google Scholar
Taylor E, Heyland A (2017) Evolution of thyroid hormone signaling in animals: non-genomic and genomic modes of action. Mol Cell Endocrinol 459:14–20
Article
CAS
Google Scholar
Amiard J-C, Amiard-Triquet C (2015) Ecotoxicological risk of endocrine disruptors. In: Amiard-Triquet C, Amiard JC, Mouneyrac C (eds) Aquatic ecotoxicology. Elsevier, Amsterdam, pp 355–382
Google Scholar
Jin S, Yang F, Liao T, Hui Y, Wen S, Xu Y (2012) Enhanced effects by mixtures of three estrogenic compounds at environmentally relevant levels on development of Chinese rare minnow (Gobiocypris rarus). Environ Toxicol Pharmacol 33:277–283
Article
CAS
Google Scholar
Bergman Å, Heindel JJ, Jobling S, Kidd KV, Zoeller RT (eds) (2013) State of the science of endocrine disrupting chemicals—2012. UNEP and WHO, Geneva
Google Scholar
Katsiadaki I (2019) Are marine invertebrates really at risk from endocrine-disrupting chemicals? Curr Opinion Environ Sci Health 11:37–42
Article
Google Scholar
Fourrier J, Deschamps M, Droin L, Alaux C, Fortini D, Beslay D, Le Conte Y, Devillers J, Aupinel P, Decourtye A (2015) Larval exposure to the juvenile hormone analog pyriproxyfen disrupts acceptance of and social behavior performance in adult honeybees. PLoS ONE 10(7):e0132985
Article
CAS
Google Scholar
Bergkamp L (2016) The concept of risk society as a model for risk regulation – its hidden and not so hidden ambitions, side effects, and risks. J Risk Res 20:1275–1291
Article
Google Scholar
Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR, Nichols JW, Russom CL, Schmieder PK, Serrrano JA, Tietge JE, Villeneuve DL (2010) Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ Toxicol Chem 29:730–741
Article
CAS
Google Scholar
Crane M, Norton A, Leaman J, Chalak A, Bailey A, Yoxon M, Smith J, Fenlon J (2006) Acceptability of pesticide impacts on the environment: what do United Kingdom stakeholders and the public value? Pest Man Sci 62:5–19
Article
CAS
Google Scholar
European Food Safety Authority (EFSA) (2010) Report on the PPR stakeholder workshop protection goals for environmental risk assessment of pesticides: What and where to protect? EFSA J 8:1672
Google Scholar
European Food Safety Authority Scientific Committee (EFSA SC) (2016) Guidance to develop specific protection goals options for environmental risk assessment at EFSA, in relation to biodiversity and ecosystem services. EFSA J 14:4499
Google Scholar
Hommen U, Forbes V, Grimm V, Preuss TG, Thorbek P, Ducrot V (2015) How to use mechanistic effect models in environmental risk assessment of pesticides: case studies and recommendations from the SETAC workshop MODELINK. Integr Environ Assess Manag 12:21–31
Article
CAS
Google Scholar
Noriega JA, Hortal J, Azcárate FM, Berg MP, Bonada N, Briones MJI, Del Toro I, Goulson D, Ibanez S, Landis DA, Moretti M, Potts SG, Slade EM, Stout JC, Ulyshen MD, Wackers FL, Woodcock BA, Santost AMC (2018) Research trends in ecosystem services provided by insects. Basic Appl Ecol 26:8–23
Article
Google Scholar
Watt A, Vanbergen A, Keith A (2011) Terrestrial and freshwater invertebrates. UK National Ecosystem Assessment: Technical Report, UNEP-WCMC, Cambridge pp 92–93.
Rife GS (2018) Ecosystem services provided by benthic macroinvertebrate assemblages in marine coastal zones. In: Hufnagel L (ed) Ecosystem services and global ecology. IntechOpen. https://doi.org/10.5772/intechopen.73150
Chapter
Google Scholar
Somerfield PJ (2011) Marine and estuarine invertebrates. UK National Ecosystem Assessment: Technical Report, UNEP-WCMC, Cambridge pp 91–92.
Van der Schatte OA, Jones L, Le Vay L, Christie M, Wilson J, Malham SK (2020) A global review of the ecosystem services provided by bivalve aquaculture. Rev Aquaculture 12:3–25
Article
Google Scholar
Carss DN, Brito AC, Chainho P, Ciutat A, de Montaudouin X, Otero RMF, Filgueira MI, Garbutt A, Goedknegt MA, Lynch SA, Mahony KE, Maire O, Malham SK, Orvain F, van der Schatte Oliver A, Jones L (2020) Ecosystem services provided by a non-cultured shellfish species: the common cockle Cerastoderma edule. Mar Environ Res 158:104931
Article
CAS
Google Scholar
Schröter M, van der Zanden EH, van Oudenhoven APE, Remme RP, Serna-Chavez HM, de Groot RS, Opdam P (2014) Ecosystem services as a contested concept: a synthesis of critique and counter-arguments. Conserv Lett 7:514–523
Article
Google Scholar
Becker RA, Ankley GT, Edwards SW, Kennedy S, Linkov I, Meek B, Sachana M, Segner H, Van Der Burg B, Villeneuve DL, Watanabe H, Barton-Maclaren TS (2015) Increasing scientific confidence in Adverse Outcome Pathways: application of tailored Bradford-Hill considerations for evaluating weight of evidence. Reg Toxicol Pharmacol 72:514–537
Article
Google Scholar
Edwards SW, Tan Y-M, Villeneuve DL, Meek ME, McQueen CA (2016) Adverse outcome pathways-organizing toxicological information to improve decision making. J Pharmacol Exp Ther 356:170–181
Article
CAS
Google Scholar
Hecker M, LaLone CA (2019) Adverse Outcome Pathways: moving from a scientific concept to an internationally accepted framework. Environ Toxicol Chem 38:1152–1163
Article
CAS
Google Scholar
Kramer VJ, Etterson MA, Hecker M, Murphy CA, Roesijadi G, Spade DJ, Spromberg JA, Wang M, Ankley GT (2011) Adverse outcome pathways and ecological risk assessment: bridging to population-level effects. Environ Toxicol Chem 30:64–76
Article
CAS
Google Scholar
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M (2014) Adverse outcome pathway (AOP) development I: strategies and principles. Toxicol Sci 142:312–320
Article
CAS
Google Scholar
Wheeler JR, Weltje L (2015) In response: adverse outcome pathways—an industry perspective. Environ Toxicol Chem 34:1937–1938
Article
CAS
Google Scholar
Perkins EJ, Ashauer R, Burgoon L, Conolly R, Landesmann B, Mackay C, Murphy CA, Pollesch N, Wheeler JR, Zupanic A, Scholz S (2019) Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment. Environ Toxicol Chem 38:1850–1865
Article
CAS
Google Scholar
Perkins EJ, Gayen K, Shoemaker JE, Antczak P, Burgoon L, Falciani F, Gutsell S, Hodges G, Kienzler A, Knapen D, McBride M, Willett C, Doyle FJ III, Garcia-Reyero N (2019) Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways. Altex 36:91–102
Article
Google Scholar
Lagadic L, Wheeler JR, Weltje L (2020) (Mis)use of the adverse outcome pathway concept for assessing endocrine disruption in nontarget organisms. Integr Environ Assess Manag 16:525–530
Article
Google Scholar
Knapen D, Angrish MM, Fortin MC, Katsiadaki I, Leonard M, Margiotta-Casaluci L, Munn S, O’Brien JM, Pollesch N, Smith LC, Zhang X, Villeneuve DL (2018) Adverse outcome pathway networks I: development and applications. Environ Toxicol Chem 37:1723–1733
Article
CAS
Google Scholar
Villeneuve DL, Angrish MM, Fortin MC, Katsiadaki I, Leonard M, Margiotta-Casaluci L, Munn S, O’Brien JM, Pollesch N, Smith LC, Zhang X, Knapen D (2018) Adverse outcome pathway networks II: network analytics. Environ Toxicol Chem 37:1734–1748
Article
CAS
Google Scholar
Organization for Economic Cooperation and Development (OECD) (2017) Revised Guidance Document on Developing and Assessing Adverse Outcome Pathways. Series on Testing and Assessment No. 184. ENV/JM/MONO(2013)6. OECD Environment, Health and Safety Publications, Paris, France.
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M (2014) Adverse outcome pathway development II: best practices. Toxicol Sci 142:321–330
Article
CAS
Google Scholar
Organization for Economic Cooperation and Development (OECD) (2018b) Users’ handbook supplement to the guidance document for developing and assessing AOPs. Series on Testing & Assessment No. 233 Series on Adverse Outcome Pathways No. 1. 14 February 2018 update. ENV/JM/MONO(2016)12. Paris, France.
Conolly RB, Ankley GT, Cheng WY, Mayo ML, Miller DH, Perkins EJ, Villeneuve DL, Watanabe KH (2017) Quantitative adverse outcome pathways and their application to predictive toxicology. Environ Sci Technol 51:4661–4672
Article
CAS
Google Scholar
Hecker M (2018) Non-model species in ecological risk assessment. In: Garcia-Reyero N, Murphy CA (eds) A systems biology approach to advancing adverse outcome pathways for risk assessment. Springer International Publishing, pp 107–132
Chapter
Google Scholar
Browne P, Noyes PD, Casey WM, Dix DJ (2017) Application of Adverse outcome pathways to U.S. EPA’s endocrine disruptor screening program. Environ Health Perspect 096001-1-11.
Song Y, Villeneuve DL, Toyota K, Iguchi T, Tollefsen KE (2017) Ecdysone receptor agonism leading to lethal molting disruption in arthropods: review and adverse outcome pathway development. Environ Sci Technol 51:4142–4157
Article
CAS
Google Scholar
Fay KA, Villeneuve CADL, LaLone YCA, Song K-EY, Tollefsen K-E, Ankley GT (2017) Practical approaches to adverse outcome pathway (AOP) development and weight-of-evidence evaluation as illustrated by ecotoxicological case studies. Environ Toxicol Chem 36:1429–1449
Article
CAS
Google Scholar
Allen TEH, Goodman JM, Gutsell S, Russell PJ (2014) Defining molecular initiating events in the adverse outcome pathway framework for risk assessment. Chem Res Toxicol 27:2100–2112
Article
CAS
Google Scholar
Day P, Green RM, Gross M, Weltje L, Wheeler JR (2018) Endocrine disruption: current approaches for regulatory testing and assessment of plant protection products are fit for purpose. Toxicol Lett 296:10–22
Article
CAS
Google Scholar
Kidd KA, Blanchfield PJ, Mills KH, Palace VP, Evans RE, Lazorchak JM, Flick RW (2007) Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci USA 22:8897–8901
Article
CAS
Google Scholar
Allen TEH, Goodman JM, Gutsell S, Russell PJ (2018) Using 2D structural alerts to define chemical categories for molecular initiating events. Toxicol Sci 165:213–223
Article
CAS
Google Scholar
Allen TEH, Goodman JM, Gutsell S, Russell PJ (2020) Quantitative predictions for molecular initiating events using three-dimensional quantitative structure−activity relationships. Chem Res Toxicol 33:324–332
Article
CAS
Google Scholar
Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DGJ (2008) Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol 42:5807–5813
Article
CAS
Google Scholar
Kostich MS, Lazorchak JM (2008) Risks to aquatic organisms posed by human pharmaceutical use. Sci Total Environ 389:329–339
Article
CAS
Google Scholar
Lalone CA, Berninger JP, Villeneuve DL, Ankley GT (2014) Leveraging existing data for prioritization of the ecological risks of human and veterinary pharmaceuticals to aquatic organisms. Philos Trans R Soc B 369:20140022
Article
Google Scholar
Mellor CL, Tollefsen KE, LaLone C, Cronin MTD, Firman JW (2020) In silico identification of chemicals capable of binding to the ecdysone receptor. Environ Toxicol Chem 39:1438–1450
Article
CAS
Google Scholar
Brockmeier EK, Hodges G, Hutchinson TH, Butler E, Hecker M, Tollefsen KE, Garcia-Reyero N, Kille P, Becker D, Chipman K (2017) The role of omics in the application of adverse outcome pathways for chemical risk assessment. Toxicol Sci 158:252–262
Article
CAS
Google Scholar
Martyniuk CJ, Simmons DB (2016) Spotlight on environmental omics and toxicology: a long way in a short time. Comp Biochem Physiol D 19:97–101
CAS
Google Scholar
McBride MT (2018) The application of omics data to the development of AOPs. In: Garcia-Reyero N, Murphy CA (eds) A systems biology approach to advancing adverse outcome pathways for risk assessment. Springer International Publishing, pp 177–198
Chapter
Google Scholar
Thomas RS, Cheung R, Westphal M, Krewski D, Andersen ME (2017) Risk science in the 21st century: a data-driven framework for incorporating new technologies into chemical safety assessment. Int J Risk Assess Manag 20:88–108
Article
Google Scholar
Van Aggelen G, Ankley GT, Baldwin WS, Bearden DW, Benson WH, Chipman JK, Collette TW, Craft JA, Denslow ND, Embry MR, Falciani F, George SG, Helbing CC, Hoekstra PF, Iguchi T, Kagami Y, Katsiadaki I, Kille P, Liu L, Lord PG, McIntyre T, O’Neill A, Osachoff H, Perkins EJ, Santos EM, Skirrow RC, Snape JR, Tyler CR, Versteeg D, Viant MR, Volz DC, Williams TD, Yu L (2010) Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook. Environ Health Perspect 118:1–5
Article
CAS
Google Scholar
Khammash M (2018) Reverse engineering: the architecture of biological networks. Biotechniques 44:323–328
Article
Google Scholar
Leonard J, Bell S, Oki N, Nelms M, Tan Y-M, Edwards S (2018) Tiered approaches to incorporate the adverse outcome pathway framework into chemical-specific risk-based decision making. In: Garcia-Reyero N, Murphy CA (eds) A systems biology approach to advancing adverse outcome pathways for risk assessment. Springer International Publishing, pp 235–261
Chapter
Google Scholar
Perkins EJ, Chipman JK, Edwards S, Habib T, Falciani F, Taylor R, Van Aggelen G, Vulpe C, Antczak P, Loguinov A (2011) Reverse engineering adverse outcome pathways. Environ Toxicol Chem 30:22–38
Article
CAS
Google Scholar
Quercioli D, Roli A, Morandi E, Perdichizzi S, Polacchini L, Rotondo F, Vaccari M, Villani M, Serra R, Colacci A (2018) The use of omics-based approaches in regulatory toxicology: an alternative approach to assess the no observed transcriptional effect level. Microchem J 136:143–148
Article
CAS
Google Scholar
Sewell F, Gellatly N, Beaumont M, Burden N, Currie R, de Haan L, Hutchinson TH, Jacobs M, Mahony C, Malcomber I, Mehta J, Whale G, Kimber I (2018) The future trajectory of adverse outcome pathways: a commentary. Arch Toxicol 92:1657–1661
Article
Google Scholar
Villaverde AF, Banga JR (2014) Reverse engineering and identification in systems biology: strategies, perspectives and challenges. J R Soc Interface 11:20130505
Article
Google Scholar
Vinken M (2019) Omics-based input and output in the development and use of adverse outcome pathways. Curr Opinion Toxicol 18:8–12
Article
Google Scholar
Oliveira E, Barata C, Piña B (2016) Endocrine disruption in the omics era: new views, new hazards, new approaches. Open Biotech J 10:20–35
Article
CAS
Google Scholar
Ankley G, LaLone C, Gray LE, Villeneuve D, Hornung M (2016) Evaluation of the scientific underpinnings for identifying estrogenic chemicals in non-mammalian taxa using mammalian test systems. Environ Toxicol Chem 35:2806–2816
Article
CAS
Google Scholar
Piersma AH, Burgdorf T, Louekari K, Desprez B, Taalman R, Landsiedel R, Barroso J, Rogiers V, Eskes C, Oelgeschläger M, Whelan M, Braeuning A, Vinggaard AM, Kienhuis A, van Benthem J, Ezendam J (2018) Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies. Toxicol In Vitro 50:62–74
Article
CAS
Google Scholar
Castro LFC, Santos MM (2014) “To bind or not to bind”: the taxonomic scope of nuclear receptor mediated endocrine disruption in invertebrate phyla. Environ Sci Technol 48:5361–5363
Article
CAS
Google Scholar
Giacomotto J, Ségalat L (2010) High-throughput screening and small animal models, where are we? Br J Pharmacol 160:204–216
Article
CAS
Google Scholar
Kaur P, Singh A, Chana I (2021) Computational techniques and tools for omics data analysis: state-of-the-art, challenges, and future directions. Arch Computat Methods Eng 28:4595–4631
Article
Google Scholar
Wittwehr C, Aladjov H, Ankley GT, Byrne HJ, de Knecht J, Henzie E, Klambauer G, Landesmann B, Luijten M, MacKay C, Maxwell G, Meek ME, Paini A, Perkins E, Sobanski T, Villeneuve D, Waters KM, Whelan M (2017) How adverse outcome pathways can aid the development and use of computational prediction models for regulatory toxicology. Toxicol Sci 155:326–336
Article
CAS
Google Scholar
Hodges G, Gutsell S, Taylor N, Brockmeier E, Butler E, Rendal C, Colbourne J (2018) Invertebrate model species in AOP development. In: Garcia-Reyero N, Murphy CA (eds) A systems biology approach to advancing adverse outcome pathways for risk assessment. Springer International Publishing, pp 75–106
Chapter
Google Scholar
LaLone CA, Villeneuve DL, Lyons D, Helgen HW, Robinson SL, Swintek JA, Saari TW, Ankley GT (2016) Editor’s highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): a web-based tool for addressing the challenges of cross-species extrapolation of chemical toxicity. Toxicol Sci 153:228–245
Article
CAS
Google Scholar
Filer D, Patisaul HB, Schug T, Reif D, Thayer K (2014) Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II. Curr Opinion Pharmacol 19:145–152
Article
CAS
Google Scholar
Kavlock R, Chandler K, Houck K, Hunter S, Judson R, Kleinstreuer N, Knudsen T, Martin M, Padilla S, Reif D, Richard A, Rotroff D, Sipes N, Dix D (2012) Update on EPA’s ToxCast program: providing high throughput decision support tools for chemical risk management. Chem Res Toxicol 25:1287–1302
Article
CAS
Google Scholar
Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix DJ, Kavlock RJ (2010) Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environ Health Perspect 118:1714–1720
Article
CAS
Google Scholar
Rotroff DM, Dix DJ, Houck KA, Knudsen TB, Martin MT, McLaurin KW, Reif DM, Crofton KM, Singh AV, Xia M, Huang R, Judson RS (2013) Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals. Environ Health Perspect 121:7–14
Article
CAS
Google Scholar
Madden JC, Rogiers V, Vinken M (2014) Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife. Philos Trans R Soc Lond B Biol Sci 369(1656):20130584
Article
CAS
Google Scholar
Schroeder AL, Ankley GT, Houck KA, Villeneuve DL (2016) Environmental surveillance and monitoring -the next frontiers for high-throughput toxicology. Environ Toxicol Chem 35:513–525
Article
CAS
Google Scholar
Judson R, Houck K, Watt E, Thomas RS (2017) On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity. Regul Toxicol Pharmacol 91:39–49
Article
CAS
Google Scholar
Mihaich EM, Schäfers C, Dreier DA, Hecker M, Ortego L, Kawashima Y, Dang Z-C, Solomon K (2017) Challenges in assigning endocrine-specific modes of action: Recommendations for researchers and regulators. Integr Environ Assess Manag 13:280–292
Article
Google Scholar
LaLone CA, Villeneuve DL, Burgoon LD, Russom CL, Helgen HW, Berninger JP, Tietge JE, Severson MN, Cavallin JE, Ankley GT (2013) Molecular target sequence similarity as a basis for species extrapolation to assess the ecological risk of chemicals with known modes of action. Aquat Toxicol 144(145):141–154
Article
CAS
Google Scholar
LaLone CA, Villeneuve DL, Cavallin JE, Kahl MD, Durhan EJ, Makynen EA, Jensen KM, Stevens KE, Severson MN, Blanksma CA, Flynn KM, Hartig PC, Woodard JS, Berninger JP, Norberg-King TJ, Johnson RD, Ankley GT (2013) Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone. Environ Toxicol Chem 32:2528–2541
CAS
Google Scholar
LaLone C, Villeneuve DL, Doering JA, Blackwell BR, Transue TR, Simmons CW, Swintek J, Degitz SJ, Williams AJ, Ankley GT (2018) Evidence for cross species extrapolation of mammalian-based high-throughput screening assay results. Environ Sci Technol 52:13960–13971
Article
CAS
Google Scholar
Houck KA, Simha A, Bone A, Doering JA, Vliet SMF, LaLone C, Medvedev A, Makarov S (2021) Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment. Toxicol In Vitro 72:105016
Article
CAS
Google Scholar
Coady K, Browne P, Embry M, Hill T, Leinala E, Steeger T, Maślankiewicz L, Hutchinson T (2019) When are adverse outcome pathways and associated assays “fit for purpose” for regulatory decision-making and management of chemicals? Integr Environ Assess Manag 15:633–647
Article
Google Scholar
United States Environmental Protection Agency (USEPA) (2017) Continuing development of alternative high‐throughput screens to determine endocrine disruption, focusing on androgen receptor, steroidogenesis, and thyroid pathways. White paper developed for the FIFRA SAP, November 28‐30, 2017. 159 p. https://www.epa.gov/sap/meeting-materials-november-28-30-2017-scientific-advisory-panel
Budd GE, Mann RP (2020) The dynamics of stem and crown groups. Sci Adv 6:eaaz1626
Article
Google Scholar
Erwin DH, Laflamme M, Tweedt SM, Sperling EA, Pisani D, Peterson KJ (2011) The Cambrian conundrum: early divergence and later ecological success in the early history of animals. Science 334:1091–1097
Article
CAS
Google Scholar
Erwin DH (2015) Early metazoan life: divergence, environment and ecology. Phil Trans R Soc B 370:20150036
Article
Google Scholar
Howe PL, Reichelt-Brushett AJ, Clark MW (2012) Aiptasia pulchella: a tropical cnidarian representative for laboratory ecotoxicological research. Environ Tox Chem 34:2653–2662
Article
CAS
Google Scholar
Howe PL, Reichelt-Brushett AJ, Clark MW (2014) Development of a chronic, early life-stage sub-lethal toxicity test and recovery assessment for the tropical zooxanthellate sea anemone Aiptasia pulchella. Ecotoxicol Environ Saf 100:138–147
Article
CAS
Google Scholar
Howe PL, Reichelt-Brushett AJ, Krassoi R, Micevska T (2015) Comparative sensitivity of the cnidarian Exaiptasia pallida and a standard toxicity test suite: testing whole effluents intended for ocean disposal. Environ Sci Pollut Res Int 22:13225–13233
Article
CAS
Google Scholar
Devillers D, Devillers H (2013) Population dynamics models for assessing the endocrine disruption potential of juvenile hormone analogues on nontarget species. In: Devillers J (ed) Juvenile hormones and Juvenoids: modeling biological effects and environmental fate. CRC Press, Boca Raton, FL, pp 127–144
Chapter
Google Scholar
Hill RL (1997) Incorporating toxic disturbance effects into a population model of a crustacean fishery. Proc Gulf Caribb Fish Inst 49:139–155
Google Scholar
Kuhn A, Munns WR Jr, Poucher S, Champlin D, Lussier S (2009) Prediction of population-level response from mysid toxicity test data using population modeling techniques. Environ Toxicol Chem 19:2364–2371
Article
Google Scholar
Raimondo S, McKenney CL Jr (2005) Projecting population-level responses of mysids exposed to an endocrine disrupting chemical. Integr Comp Biol 45:151–157
Article
CAS
Google Scholar
Tanaka Y (2003) Ecological risk assessment of pollutant chemicals: extinction risk based on population-level effects. Chemosphere 53:421–425
Article
CAS
Google Scholar
Thompson HM, Wilkins S, Battersby AH, Waite RJ, Wilkinson D (2007) Modelling long-term effects of IGRs on honeybee colonies. Pest Manag Sci 63:1081–1084
Article
CAS
Google Scholar
Devillers J, Devillers H, Decourtye A, Fourrier J, Aupinel P, Fortini D (2014) Agent-based modeling of the long-term effects of pyriproxyfen on honeybee population. In: Devillers J (ed) In silico bees. CRC Press, Boca Raton, FL
Chapter
Google Scholar
Rico A, Van den Brink PJ (2015) Evaluating aquatic invertebrate vulnerability to insecticides based on intrinsic sensitivity, biological traits, and toxic mode of action. Environ Toxicol Chem 34:1907–1917
Article
CAS
Google Scholar
Rubach MN, Ashauer R, Buchwalter DB, De Lange HJ, Hamer M, Preuss TG, Töpke K, Maund SJ (2011) Framework for traits-based assessment in ecotoxicology. Integr Environ Assess Manag 7:172–186
Article
Google Scholar
Van den Berg SJP, Baveco H, Butler E, De Laender F, Focks A, Franco A, Rendal C, Van den Brink PJ (2019) Modeling the sensitivity of aquatic macroinvertebrates to chemicals using traits. Environ Sci Technol 53:6025–6034
Article
CAS
Google Scholar
Rubach MN, Baird DJ, Van den Brink PJ (2010) A new method for ranking mode-specific sensitivity of freshwater arthropods to insecticides and its relationship to biological traits. Environ Toxicol Chem 29:476–487
Article
CAS
Google Scholar
Forbes VE, Olsen M, Palmqvist A, Calow P (2010) Environmentally sensitive life-cycle traits have low elasticity: implications for theory and practice. Ecol Appl 20:1449–1455
Article
Google Scholar
Pfister CA (1998) Patterns of variance in stage-structured populations: evolutionary predictions and ecological implications. PNAS 95:213–219
Article
CAS
Google Scholar
European Food Safety Authority Scientific Committee (EFSA SC) (2017) Scientific opinion on guidance on the assessment of the biological relevance of data in scientific assessments. EFSA J 15:4970
Google Scholar
Forbes VE, Salice CJ, Birnir B, Bruins RJF, Calow P, Ducrot V, Galic N, Garber K, Harvey BC, Jager H, Karanek A, Pastorok R, Railsback SF, Rebarber R, Thorbek P (2017) A framework for predicting impacts on ecosystem services from (sub)organismal responses to chemicals. Environ Toxicol Chem 36:845–859
Article
CAS
Google Scholar
Forbes VE, Galic N, Schmolke A, Vavra J, Pastorok R, Thorbek P (2016) Assessing the risks of pesticides to threatened and endangered species using population modeling: a critical review and recommendations for future work. Environ Toxicol Chem 35:1904–1913
Article
CAS
Google Scholar
Kubickova B, Ramwell C, Hilscherova K, Jacobs MN (2021) Highlighting the gaps in hazard and risk assessment of unregulated Endocrine Active Substances in surface waters: retinoids as a European case study. Environ Sci Eur 33:20
Article
Google Scholar
Vogeler S, Galloway TS, Isupov M, Bean TP (2017) Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. PLoS ONE 12(4):e0176024
Article
CAS
Google Scholar
Bopp S, Nepelska M, Halder M, Munn S (2017) Expert survey on identification of gaps in available test methods for evaluation of endocrine disruptors; JRC Technical Report, EUR 28592 EN, Luxembourg.