|
MIE
|
EcR, activation
|
Macromolecular
|
D
|
S
|
S
|
S
|
S
|
W
|
In vitro ECR binding assay; transcriptional analysis
|
EcR transfected mammalian cells; mRNA from cell, tissue, and whole organism
|
|
KE-1
|
E75b gene, induction
|
Molecular/cellular
|
D
|
S
|
S
|
S
|
S
|
W
|
Transcriptional analysis
|
mRNA from cell, tissue, and whole organism
|
|
KE-2
|
Ftz-f1 gene, suppression
|
Molecular/cellular
|
D
|
M
|
S
|
M
|
M
|
W
|
Transcriptional analysis
|
mRNA from cell, tissue, and whole organism
|
|
KE-3
|
Release of circulating Eth, reduction
|
Tissue/organ
|
I
|
S
|
S
|
M
|
M
|
W
|
Enzyme immunoassay; immunohistochemical staining
|
Haemolymph; isolated endocrine tissue
|
|
KE-4
|
Release of circulating Ccap, reduction
|
Tissue/organ
|
D
|
S
|
S
|
M
|
M
|
W
|
Enzyme immunoassay; immunohistochemical staining
|
Haemolymph; isolated endocrine tissue
|
|
KE-5
|
Ecdysis motoneuron bursts, reduction
|
Tissue/organ
|
D
|
S
|
S
|
M
|
M
|
W
|
Electrophysiological recording
|
Isolated CNS, abdominal ganglion
|
|
KE-6
|
Excitatory postsynaptic potential, reduction
|
Tissue/organ
|
D
|
M
|
S
|
M
|
M
|
W
|
Electrophysiological recording; FM1-43 fluorescent labelling
|
Skeletal muscles
|
|
KE-7
|
Abdominal muscle contraction, reduction
|
Tissue/organ
|
D
|
M
|
S
|
M
|
M
|
W
|
Electrophysiological recording; behavioural (air/water swallowing) assays
|
Skeletal muscles; whole organism
|
|
KE-8
|
Incomplete ecdysis, induction
|
Individual
|
D
|
S
|
S
|
S
|
S
|
S
|
Light microscope, histopathology
|
Cuticle; whole organism
|
|
AO
|
Mortality, increased
|
Individual
|
D
|
S
|
S
|
S
|
S
|
St
|
Survival test
|
Whole organism
|
