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Table 3 Association between maternal blood metal concentrations during first trimester with spontaneous preterm birth risk

From: Associations between maternal blood metal concentrations during the first trimester and spontaneous preterm birth: a nested case-control study

Variables

Preterm birth/Control

Model 1a

P

Model 2b

P

n (%)

Odds ratio (95% CI)

Odds ratio (95%CI)

V

 Q1c

15 (12.5)/46 (38.3)

    

 Q2d

26 (21.7)/34 (28.3)

2.30 (1.01,5.26)

0.047

2.22 (0.91,5.41)

0.080

 Q3e

35 (29.2)/26 (21.7)

2.99 (1.34,6.65)

0.007

3.36 (1.39,8.13)

0.007

 Q4f

44 (36.7)/14 (11.7)

5.91 (2.63,13.31)

 < 0.001

5.76 (2.46,13.53)

 < 0.001

 Ptrend

  

 < 0.001

 

 < 0.001

Ca

 Q1

31 (25.8)/31 (25.8)

    

 Q2

35 (29.2)/32 (26.7)

1.10 (0.55,2.20)

0.791

1.01 (0.48,2.14)

0.975

 Q3

29 (24.2)/31 (25.8)

0.94 (0.47,1.87)

0.860

0.99 (0.44,2.23)

0.973

 Q4

25 (20.8)/26 (21.7)

0.98 (0.46,2.06)

0.948

1.03 (0.50,2.16)

0.930

 Ptrend

  

0.818

 

0.996

Cd

 Q1

33 (27.5)/27 (22.5)

    

 Q2

27 (22.5)/34 (28.3)

0.63 (0.30,1.32)

0.220

0.61 (0.27,1.38)

0.233

 Q3

29 (24.2)/30 (25.0)

0.83 (0.41,1.68)

0.598

0.79 (0.37,1.68)

0.537

 Q4

31 (25.8)/29 (24.2)

0.91 (0.46,1.78)

0.777

0.89 (0.42,1.90)

0.771

 Ptrend

  

0.867

 

0.854

Li

 Q1

27 (22.5)/34 (28.3)

    

 Q2

37 (30.8)/22 (18.3)

1.92 (0.95,3.87)

0.069

1.55 (0.72,3.34)

0.260

 Q3

25 (20.8)/36 (30.0)

0.81 (0.39,1.68)

0.566

0.99 (0.45,2.16)

0.980

 Q4

31 (25.8)/28 (23.3)

1.26 (0.64,2.46)

0.499

1.33 (0.64,2.75)

0.445

 Ptrend

  

0.913

 

0.627

Mg

 Q1

28 (23.3)/45 (37.5)

    

 Q2

25 (20.8)/29 (24.2)

1.38 (0.68,2.77)

0.37

1.45 (0.68,3.09)

0.333

 Q3

28 (23.3)/28 (23.3)

1.50 (0.77,2.94)

0.237

1.54 (0.74,3.20)

0.243

 Q4

39 (32.5)/18 (15.0)

3.27 (1.56,6.85)

0.002

3.64 (1.64,8.09)

0.002

 Ptrend

  

0.002

 

0.003

Mn

 Q1

38 (31.7)/22 (18.3)

    

 Q2

30 (25.0)/30 (25.0)

0.57 (0.27,1.21)

0.141

0.42 (0.18,0.96)

0.041

 Q3

23 (19.2)/37 (30.8)

0.34 (0.16,0.75)

0.008

0.32 (0.13,0.76)

0.010

 Q4

29 (24.2)/31 (25.8)

0.58 (0.29,1.18)

0.133

0.53 (0.24,1.16)

0.111

 Ptrend

  

0.066

 

0.095

Mo

 Q1

33 (27.5)/29 (24.2)

    

 Q2

31 (25.8)/29 (24.2)

0.91 (0.44,1.88)

0.796

0.97 (0.43,2.19)

0.947

 Q3

27 (22.5)/33 (27.5)

0.70 (0.33,1.48)

0.353

0.60 (0.26,1.35)

0.216

 Q4

29 (24.2)/29 (24.2)

0.86 (0.39,1.89)

0.709

0.89 (0.36,2.21)

0.803

 Ptrend

  

0.536

 

0.405

Pb

 Q1

42 (35.0)/44 (36.7)

    

 Q2

20 (16.7)/32 (26.7)

0.66 (0.33,1.33)

0.241

0.46 (0.21,1.02)

0.057

 Q3

28 (23.3)/21 (17.5)

1.41 (0.65,3.02)

0.382

1.57 (0.69,3.59)

0.286

 Q4

30 (25.0)/23 (19.2)

1.37 (0.71,2.66)

0.346

1.27 (0.61,2.64)

0.519

 Ptrend

  

0.224

 

0.270

As

 Q1

31 (25.8)/29 (24.2)

    

 Q2

24 (20.0)/36 (30.0)

0.64 (0.31,1.31)

0.221

0.48 (0.22,1.05)

0.067

 Q3

31 (25.8)/29 (24.2)

0.97 (0.47,2.00)

0.925

0.98 (0.43,2.21)

0.960

 Q4

34 (28.3)/26 (21.7)

1.26 (0.59,2.68)

0.549

1.15 (0.50,2.64)

0.735

 Ptrend

  

0.349

 

0.377

Sr

 Q1

36 (30.0)/24 (20.0)

    

 Q2

27 (22.5)/33 (27.5)

0.50 (0.23,1.08)

0.079

0.54 (0.24,1.22)

0.140

 Q3

35 (29.2)/26 (21.7)

0.96 (0.44,2.07)

0.908

0.99 (0.42,2.32)

0.983

 Q4

22 (18.3)/37 (30.8)

0.39 (0.18,0.84)

0.015

0.39 (0.17,0.91)

0.029

 Ptrend

  

0.063

 

0.078

Fe

 Q1

28 (23.3)/38 (31.7)

    

 Q2

26 (21.7)/30 (25.0)

1.15 (0.57,2.32)

0.692

1.05 (0.49,2.25)

0.907

 Q3

35 (29.2)/23 (19.2)

2.01 (0.99,4.10)

0.054

1.56 (0.75,3.28)

0.236

 Q4

31 (25.8)/29 (24.2)

1.47 (0.70,3.09)

0.304

1.70 (0.78,3.72)

0.182

 Ptrend

  

0.131

 

0.116

Cu

 Q1

23 (19.2)/37 (30.8)

    

 Q2

29 (24.2)/31 (25.8)

1.35 (0.64,2.86)

0.428

1.06 (0.48,2.38)

0.880

 Q3

30 (25.0)/30 (25.0)

1.41 (0.67,2.94)

0.366

1.35 (0.60,3.01)

0.465

 Q4

38 (31.7)/22 (18.3)

2.53 (1.23,5.20)

0.012

2.88 (1.29,6.41)

0.010

 Ptrend

  

0.015

 

0.010

Se

 Q1

28 (23.3)/32 (26.7)

    

 Q2

26 (21.7)/34 (28.3)

0.88 (0.44,1.76)

0.723

0.91 (0.44,1.89)

0.801

 Q3

33 (27.5)/27 (22.5)

1.54 (0.71,3.31)

0.273

1.64 (0.73,3.69)

0.233

 Q4

33 (27.5)/27 (22.5)

1.48 (0.70,3.12)

0.308

1.49 (0.67,3.32)

0.329

 Ptrend

  

0.187

 

0.208

Zn

 Q1

28 (23.3)/32 (26.7)

    

 Q2

29 (24.2)/31 (25.8)

1.09 (0.54,2.21)

0.814

1.12 (0.52,2.41)

0.780

 Q3

26 (21.7)/34 (28.3)

0.90 (0.43,1.90)

0.787

0.86 (0.38,1.92)

0.705

 Q4

37 (30.8)/23 (19.2)

1.98 (0.91,4.33)

0.086

2.30 (1.00,5.28)

0.049

 Ptrend

  

0.146

 

0.091

  1. aThe model without adjustment
  2. bThe model adjusted for sampling gestational age, sex of the fetus, education level of the mother, monthly family income, passive smoking and folate intake
  3. c< 25th quantile
  4. d25th–50th quantile
  5. e50th–75th quantile
  6. f> 75th quantile