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Table 3 Bioaccumulation metrics and corresponding scores indicating bioaccumulation potential. The composite bioaccumulation score \({S}_{stock(bio)}\) is the average of the scores assigned to the available bioaccumulation metrics

From: Scoring scheme for Comparative Ranking of impact potential of chemical Alternatives (SCoRA)

Level of concern

BCF

BMF

Log Kow

Log Koa (and log Kow > 2)*

Accumulation related to protein binding**

Elimination half-life [d] incl. metabolism***

Score

Very low

 < 100

 < 0.01

 < 1

 < 1

no

–

1

Low

100–< 1000

0.01–< 0.1

1–< 2

1–< 4

–

 < 70

2

Moderate

1000–< 2000

0.1–< 1

2–< 3

4–< 5

–

–

3

High

2000–< 5000

1–< 2

3–< 4.5

5–< 10

–

 ≥ 70

5

Very high

 ≥ 5000

 ≥ 2

 ≥ 4.5

 ≥ 10

yes

–

10

  1. *The log Kow > 2 is a prerequisite for accumulation in air-breathing organisms. If log Kow is < 2, the respective score for log Koa is always 1.
  2. **May be detailed when scales of protein binding related to bioaccumulation will become available.
  3. ***According to Goss et al. [65].