Toxicological effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on the skeletal muscle of mice during the perinatal period: a metabolomics study

Environmental Sciences Europe

Table 2 Differential metabolites detected in the skeletal muscle tissues of the 4 groups of female mice by metabolomic analysis based on GC–MS

No.	Metabolite	Mean component content (%)^a				p-value^b
No.	Metabolite	Nonane/Nonane	Nonane/TCDD	TCDD/Nonane	TCDD/TCDD	p-value^b
Soleus
1	Phosphate	11.63	15.43	11.94	16.82	0.03692**
2	2-E-Butenedioic acid	0.00	0.1556	0.1916	0.01698	0.02833**
3	L5-Oxoproline	0.3559	0.5469	2.277	0.2484	0.06245*
4	L-Glutamic acid	4.475	4.588	1.624	3.572	0.03382**
5	α-D-Glucose	0.5780	0.7943	0.4351	0.3977	0.05407*
6	Myo-inositol	0.6384	0.9833	0.2719	0.3126	0.03856**
Plantaris
1	L5-oxoproline	2.314	2.299	0.9395	2.1667	0.01982**
2	Pyrophosphate	0.2876	0.5334	0.07675	0.4502	0.003732***
Gastrocnemius
1	Lactic acid	11.51	10.07	3.325	13.40	0.01405**
2	Phosphate	17.87	22.02	19.62	21.77	0.03678**
3	Creatinine	10.79	11.46	5.808	9.119	0.03627**
4	L-Phenylalanine	0.5059	0.4995	0.7667	0.5889	0.02154**
5	Hypoxanthine	0.2993	0.1961	0.4304	0.3362	0.002964***
6	α-D-Glucose	1.571	1.495	3.127	1.319	0.07139*
7	L-Tyrosine	0.2038	0.09722	0.5351	0.279	0.01280**
8	Arachidonic acid	1.869	2.099	1.495	1.595	0.03868**
9	Squalene	1.958	2.180	1.103	0.7884	0.01573**

^aThe percentage of the ratios of the areas of the intended signals to the total signal of the chromatogram
^bThe p-value of p < 0.1*, p < 0.05** and p < 0.01*** indicates that the result is significant