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Table 1 Regulatory issues for which different NTS approaches, including suspect screening, can be supportive

From: High resolution mass spectrometry-based non-target screening can support regulatory environmental monitoring and chemicals management

Legislation Regulatory context NTS approaches (several for each context)
Environmental legislation
 Water Framework Directive (WFD)
 Marine Strategy Framework Directive (MSFD)
 Ambient Air Quality Directive
 Drinking Water Directive
 Industrial Emissions Directive
Environmental monitoring Spatial/temporal trend analysis to identify relevant unknown pollutants
Implementation of field systems for real-time warning
Screening for large numbers of substances including suspected compounds
Food legislation
 Regulation on maximum levels for certain contaminants in food
 Regulation on food additives
 Regulation on residues of veterinary medicinal products
 Regulation on residues of plant protection products
 Regulation on Authenticity
Food monitoring including control of food authenticity, fraud and adulteration Screening for substance classes through e.g. specific mass fragmentation or isotope pattern
Substance legislation
 REACH Regulation
 Plant Protection Products and Biocidal Products Regulation
 Human and veterinary medicinal products Directives
 Food contact materials Regulation
Chemicals management such as detection of leakages and unintentional discharges
Prioritization (e.g. PBT, PMT screening)
Before-after monitoring to determine effectiveness of mitigation measures (e.g. new technologies)
Retrospective exploitation of digital data
Worker protection legislation
 Carcinogens and mutagens Directive
 Chemical agents Directive
Human bio-monitoring Effect-directed analysis
  1. PBT persistent, bioaccumulative, toxic; PMT persistent, mobile, toxic