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Table 3 The results of blood biochemical indexes of rats treated with coppers

From: Liver toxicity assessments in rats following sub-chronic oral exposure to copper nanoparticles

 

ALT

AST

AST/ALT

ALP

ALB

GLB

A/G

Control

61.40 ± 8.0

166.57 ± 17.73

2.96 ± 0.51

204.39 ± 33.39

34.47 ± 2.26

30.77 ± 3.88

1.14 ± 0.17

Micro-copper

63.14 ± 4.14

221.41 ± 14.62**

3.63 ± 0.58

232.78 ± 47.38*

33.94 ± 1.14

25.25 ± 6.00**

1.40 ± 0.26**

CuCl2·2H2O

65.17 ± 6.64

174.03 ± 13.63

2.69 ± 0.29

251.79 ± 34.34*

34.61 ± 1.19

21.74 ± 3.41**

1.63 ± 0.26**

Nano-copper 50 mg/kg

55.18 ± 2.44

161.48 ± 22.80

3.09 ± 0.93

204.34 ± 9.04

32.96 ± 2.19*

23.31 ± 2.94**

1.43 ± 0.12**

Nano-copper 100 mg/kg

59.50 ± 4.90

173.76 ± 17.08

2.92 ± 0.42

209.12 ± 12.35

32.34 ± 2.08*

23.11 ± 3.21**

1.42 ± 0.15**

Nano-copper 200 mg/kg

61.11 ± 7.81

220.60 ± 23.29**

3.61 ± 0.37

237.06 ± 9.36*

31.48 ± 1.12**

23.11 ± 2.25**

1.38 ± 0.15**

 

TC

CK

GLU

TP

UREA

CREA

TG

Control

1.70 ± 0.43

1076.47 ± 351.89

10.43 ± 3.69

65.23 ± 3.19

8.37 ± 1.14

26.43 ± 5.22

0.42 ± 0.14

Micro-copper

1.67 ± 0.31

1442.84 ± 493.35*

11.08 ± 1.21

55.94 ± 1.70**

9.47 ± 2.51

16.41 ± 6.39**

0.61 ± 0.22

CuCl2·2H2O

1.97 ± 0.29

936.51 ± 193.07

11.11 ± 2.60

56.36 ± 3.86**

6.35 ± 1.11*

15.52 ± 4.01**

0.80 ± 0.21**

Nano-copper 50 mg/kg

1.50 ± 0.35

908.97 ± 459.04

12.06 ± 1.54

56.27 ± 4.76**

5.07 ± 1.76**

15.47 ± 2.19**

0.62 ± 0.13*

Nano-copper 100 mg/kg

1.54 ± 0.36

510.5 ± 236.76**

10.83 ± 2.26

55.46 ± 4.88**

4.65 ± 1.16**

16.31 ± 6.93**

0.72 ± 0.30**

Nano-copper 200 mg/kg

1.34 ± 0.27*

386.33 ± 204.55**

10.05 ± 1.26

54.59 ± 1.99**

5.12 ± 2.11**

21.79 ± 4.39*

0.60 ± 0.27

  1. ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, A/G albumin/globulin, CK creatine kinase, GLB globulin, TP total protein, CREA creatinine, TG triglyceride, ALB albumin, TC cholesterol
  2. *p < 0.05; **p < 0.01