From: Liver toxicity assessments in rats following sub-chronic oral exposure to copper nanoparticles
 | ALT | AST | AST/ALT | ALP | ALB | GLB | A/G |
---|---|---|---|---|---|---|---|
Control | 61.40 ± 8.0 | 166.57 ± 17.73 | 2.96 ± 0.51 | 204.39 ± 33.39 | 34.47 ± 2.26 | 30.77 ± 3.88 | 1.14 ± 0.17 |
Micro-copper | 63.14 ± 4.14 | 221.41 ± 14.62** | 3.63 ± 0.58 | 232.78 ± 47.38* | 33.94 ± 1.14 | 25.25 ± 6.00** | 1.40 ± 0.26** |
CuCl2·2H2O | 65.17 ± 6.64 | 174.03 ± 13.63 | 2.69 ± 0.29 | 251.79 ± 34.34* | 34.61 ± 1.19 | 21.74 ± 3.41** | 1.63 ± 0.26** |
Nano-copper 50 mg/kg | 55.18 ± 2.44 | 161.48 ± 22.80 | 3.09 ± 0.93 | 204.34 ± 9.04 | 32.96 ± 2.19* | 23.31 ± 2.94** | 1.43 ± 0.12** |
Nano-copper 100 mg/kg | 59.50 ± 4.90 | 173.76 ± 17.08 | 2.92 ± 0.42 | 209.12 ± 12.35 | 32.34 ± 2.08* | 23.11 ± 3.21** | 1.42 ± 0.15** |
Nano-copper 200 mg/kg | 61.11 ± 7.81 | 220.60 ± 23.29** | 3.61 ± 0.37 | 237.06 ± 9.36* | 31.48 ± 1.12** | 23.11 ± 2.25** | 1.38 ± 0.15** |
 | TC | CK | GLU | TP | UREA | CREA | TG |
---|---|---|---|---|---|---|---|
Control | 1.70 ± 0.43 | 1076.47 ± 351.89 | 10.43 ± 3.69 | 65.23 ± 3.19 | 8.37 ± 1.14 | 26.43 ± 5.22 | 0.42 ± 0.14 |
Micro-copper | 1.67 ± 0.31 | 1442.84 ± 493.35* | 11.08 ± 1.21 | 55.94 ± 1.70** | 9.47 ± 2.51 | 16.41 ± 6.39** | 0.61 ± 0.22 |
CuCl2·2H2O | 1.97 ± 0.29 | 936.51 ± 193.07 | 11.11 ± 2.60 | 56.36 ± 3.86** | 6.35 ± 1.11* | 15.52 ± 4.01** | 0.80 ± 0.21** |
Nano-copper 50 mg/kg | 1.50 ± 0.35 | 908.97 ± 459.04 | 12.06 ± 1.54 | 56.27 ± 4.76** | 5.07 ± 1.76** | 15.47 ± 2.19** | 0.62 ± 0.13* |
Nano-copper 100 mg/kg | 1.54 ± 0.36 | 510.5 ± 236.76** | 10.83 ± 2.26 | 55.46 ± 4.88** | 4.65 ± 1.16** | 16.31 ± 6.93** | 0.72 ± 0.30** |
Nano-copper 200 mg/kg | 1.34 ± 0.27* | 386.33 ± 204.55** | 10.05 ± 1.26 | 54.59 ± 1.99** | 5.12 ± 2.11** | 21.79 ± 4.39* | 0.60 ± 0.27 |