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Table 3 The results of blood biochemical indexes of rats treated with coppers

From: Liver toxicity assessments in rats following sub-chronic oral exposure to copper nanoparticles

  ALT AST AST/ALT ALP ALB GLB A/G
Control 61.40 ± 8.0 166.57 ± 17.73 2.96 ± 0.51 204.39 ± 33.39 34.47 ± 2.26 30.77 ± 3.88 1.14 ± 0.17
Micro-copper 63.14 ± 4.14 221.41 ± 14.62** 3.63 ± 0.58 232.78 ± 47.38* 33.94 ± 1.14 25.25 ± 6.00** 1.40 ± 0.26**
CuCl2·2H2O 65.17 ± 6.64 174.03 ± 13.63 2.69 ± 0.29 251.79 ± 34.34* 34.61 ± 1.19 21.74 ± 3.41** 1.63 ± 0.26**
Nano-copper 50 mg/kg 55.18 ± 2.44 161.48 ± 22.80 3.09 ± 0.93 204.34 ± 9.04 32.96 ± 2.19* 23.31 ± 2.94** 1.43 ± 0.12**
Nano-copper 100 mg/kg 59.50 ± 4.90 173.76 ± 17.08 2.92 ± 0.42 209.12 ± 12.35 32.34 ± 2.08* 23.11 ± 3.21** 1.42 ± 0.15**
Nano-copper 200 mg/kg 61.11 ± 7.81 220.60 ± 23.29** 3.61 ± 0.37 237.06 ± 9.36* 31.48 ± 1.12** 23.11 ± 2.25** 1.38 ± 0.15**
  1. ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, A/G albumin/globulin, CK creatine kinase, GLB globulin, TP total protein, CREA creatinine, TG triglyceride, ALB albumin, TC cholesterol
  2. *p < 0.05; **p < 0.01
  TC CK GLU TP UREA CREA TG
Control 1.70 ± 0.43 1076.47 ± 351.89 10.43 ± 3.69 65.23 ± 3.19 8.37 ± 1.14 26.43 ± 5.22 0.42 ± 0.14
Micro-copper 1.67 ± 0.31 1442.84 ± 493.35* 11.08 ± 1.21 55.94 ± 1.70** 9.47 ± 2.51 16.41 ± 6.39** 0.61 ± 0.22
CuCl2·2H2O 1.97 ± 0.29 936.51 ± 193.07 11.11 ± 2.60 56.36 ± 3.86** 6.35 ± 1.11* 15.52 ± 4.01** 0.80 ± 0.21**
Nano-copper 50 mg/kg 1.50 ± 0.35 908.97 ± 459.04 12.06 ± 1.54 56.27 ± 4.76** 5.07 ± 1.76** 15.47 ± 2.19** 0.62 ± 0.13*
Nano-copper 100 mg/kg 1.54 ± 0.36 510.5 ± 236.76** 10.83 ± 2.26 55.46 ± 4.88** 4.65 ± 1.16** 16.31 ± 6.93** 0.72 ± 0.30**
Nano-copper 200 mg/kg 1.34 ± 0.27* 386.33 ± 204.55** 10.05 ± 1.26 54.59 ± 1.99** 5.12 ± 2.11** 21.79 ± 4.39* 0.60 ± 0.27
  1. ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, A/G albumin/globulin, CK creatine kinase, GLB globulin, TP total protein, CREA creatinine, TG triglyceride, ALB albumin, TC cholesterol
  2. *p < 0.05; **p < 0.01