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Environmental Sciences Europe
Fig. 2 | Environmental Sciences Europe

Fig. 2

From: Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

Fig. 2

Illustration of major results from literature/ToxCast/AOP search for Category I FRs. Major AOs are indicated (in ovals) with corresponding plausible AOPs (arrows with their number from the AOP-wiki) and MIE (in hexagons). A color code indicates for which Cat I FR the AOP is a plausible mechanism, or the AO or MIE has been reported. No colors at MIE indicate that the effects of FRs have not been reported so far or AC50 from ToxCast was not “verified” as explained in the text. Several other AOs, AOPs and MIEs not illustrated in this figure have been investigated and are listed in Additional file 1: Table S3. (Disclaimer: because of dynamic nature of AOP-Wiki, the information on AOPs presented in the paper reflects state of the art as of June 2018, when the information from AOP-Wiki was collected)

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