Table 2 Overview of measured endpoints and obtained responses

Fluorescent GSH detection

1 h (96–97 hpf)

↑

↑

Fluorescent ROS detection

2 h (96–98 hpf)

–

–

multixenobiotic resistance activity (MXR)

24 h (2–26 hpf)

↓

–

Multixenobiotic resistance activity (MXR)

48 (2–50 hpf)

↓

↑

In vivo enzymatic responses

 EROD activity

1 h (96–97 hpf)

–

–

 CES activity

↓

–

 GST activity

–

–

 CAT activity

–

–

 AChE activity

↓

–

In vitro enzymatic activities

 CYP2D6 activity

1 h

–

–

 CYP2A6 activity

–

–

 CYP2C9 activity

–

–

 CYP1A2 activity

↓

↓

 CYP2B6 activity

↓

–

 CYP2C19 activity

↓

↓

 CYP3A4 activity

↓

–

 AChE activity

–

↓

Gene expression measurements

 cyp1a1

48 h (72–120 hpf)

–

–

 cyp3c4

↓

↑

 cyp3a65

↓

–

 gstp1

↑

–