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Table 3 Examples of the differential toxicity of technical glyphosate and formulated GBHs in human cell assays

From: How did the US EPA and IARC reach diametrically opposed conclusions on the genotoxicity of glyphosate-based herbicides?

Assay/marker Glyphosate technical Formulated GBHs Differential Source
Viability of human peripheral blood mononuclear cells 1640 μg/mL 56.4 μg/mL 29 Martinez et al. [40]
LC 50 in HepG2 cells (ppm) 19,323 62 312 Mesnage et al. [33]
LC 50 in JEG3 cells (ppm) 1192 32 37 Mesnage et al. [33]
1/LC 50 JEG3 cells (ppm) [glyphosate IPA-salt; Roundup Classic] 0.000082 0.0081 99 Defarge et al. [32]
DNA damage to peripheral blood mononuclear cells 250 μM 5 μM [Roundup 360 PLUS] 50 Wozniak et al. [34]
LC 50 in human HepaRG cells 2 mg/mL 0.04–0.1 mg/mL 20–50 Rice et al. [41]