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Table 2 Number of genotoxicity assays cited in core tables by IARC 2017, EPA 2016, or in Monsanto-commissioned reviews

From: How did the US EPA and IARC reach diametrically opposed conclusions on the genotoxicity of glyphosate-based herbicides?

Assay type and compound tested Number of studies considered by IARC Cited by
MON reviews EPA Sept 2016
Exposed humans
 Formulated GBHs 5 5 0
Human cells in vitro
 Glyphosate 10 8 7
 AMPA 2 2 0
 Formulated GBHs 4 2 3
Non-human mammals in vivo
 Glyphosate 11 10 10
 AMPA 1 1 0
 Formulated GBHs 13 13 13
Non-human mammalian cells in vitro
 Glyphosate 5 5 5
 AMPA 1 1 0
 Formulated GBHs 2 2 2
Non-mammalian systems in vivo
 Glyphosate 12 7 1
 AMPA 2 2 0
 Formulated GBHs 40 21 4
Non-mammalian systems in vitro
 Glyphosate 8 3 4
 Formulated GBHs 2 2 2
Total all categories 118 84 51
 As percent of total IARC 71% 43%
Total of all mammalian categories 54 49 40
 As percent of total IARC 91% 74%
  1. 1. IARC totals are from the detailed accounting of all studies considered by the IARC Working Group in the glyphosate section of Monograph 112 [4]. Information on the studies are taken from Tables 4.1–4.6 and the discussion of studies on oxidative stress in humans in Sect. 4.2.3 (a) (i) of the monograph
  2. 2. “MON Reviews” include four published studies: Brusick et al. [22]; Kier and Kirkland [27]; Heydens et al. [26]; and Williams et al. [14]. The references in these four, Monsanto-commissioned reviews were cross-checked against the list of IARC studies
  3. 3. “EPA Sept 2016” refers to the September 12, 2016 “Glyphosate Issue Paper: Evaluation of Carcinogenic Potential” [3]. All studies cited in this EPA document, including in its Appendix F which contains studies on formulated glyphosate-based herbicides, were cross-checked against the studies cited by IARC and in the Monsanto-commissioned reviews