Fig. 5

Assembly of AOP networks showing all AOPs relevant to human (orange) and eco-neurotoxicity (blue) that are available in the AOP-Wiki (https://aopwiki.org; Accession date: April 30, 2018; Eco-neurotoxicity AOP numbers 16, 77, 78, 79, 80, 82, 87, 88, 89, 90, 91, 93, 94, 95, 97, 98, 99, 113, 160, 161, 178, 195, 197, 203, 204; Human neurotoxicity AOP numbers 3, 8, 10, 12, 13, 17, 26, 42, 48, 54, 73, 104, 112, 126, 134, 152, 164, 170, 214, 215, 221, 222, 223, 224, 225, 226, 230, 231, 233, 234, 235, 236; Network constructed using Cytoscape 3.6.1). Nodes in the network are key events (KEs), and edges represent key event relationships (KERs). Molecular initiating events are displayed in green, adverse outcomes in red. All other KEs are depicted in blue. Node size represents node degree (the total number of KERs connecting the KE to the network, [334]). KERs in blue are part of eco-neurotoxicity AOPs and correspond to Fig. 4, KERs in orange are part of human neurotoxicity AOPs. The AOP network does not make any inference about the scientific validity of the underlying AOPs, nor can it at this stage be used for in-depth biological interpretation or regulatory application