Fig. 1
From: Adaption of a dermal in vitro method to investigate the uptake of chemicals across amphibian skin
Absorption-time profiles of caffeine and testosterone permeation across the skin of Xenopus laevis. Mean cumulative absorbed dose ± standard deviation, found in the receptor fluids plotted against time and differentiated by skin storage and body side; mean values are based on 3–5 skin samples (as specified in brackets behind indication of skin storage and side in the diagram legends), stemming from one animal [except for testosterone data of freshly excised skin due to separation of testosterone results into 4- and 8-h exposure studies; see (Additional file 2) for 4-h testosterone data and detailed information on the individual cumulative absorbed doses]; due to incorrect sampling, testosterone data after 2 h for freshly excised skin and 3 h for frozen stored skin were excluded from this diagram