Discriminant variables
|
GMO 11%
|
GMO 22%
|
GMO 33%
|
GMO 11% + R
|
GMO 22% + R
|
GMO 33% + R
|
R (A)
|
R (B)
|
R (C)
|
---|
Gonadal hormones
|
Estradiol
|
5
|
−2
|
−25
|
8
|
−1
|
2
|
−26
|
− 73a
|
39
|
|
Testosterone
|
56a
|
17
|
81
|
5
|
−9
|
27
|
97a
|
− 72a
|
10
|
Serum decrease or increase
|
Na
|
−1
|
− 4a
|
− 6a
|
2
|
1
|
1
|
−7
|
0
|
−3
|
|
Cl
|
−5
|
−7
|
− 6a
|
−1
|
−2
|
−2
|
− 8a
|
−1
|
−4
|
|
P
|
−17
|
− 18a
|
− 20a
|
−6
|
−11
|
−13
|
− 32a
|
−9
|
−13
|
|
K
|
2
|
−4
|
0
|
4
|
5
|
10
|
−4
|
8
|
− 5a
|
|
Ca
|
2a
|
−2
|
− 5a
|
4
|
3
|
3
|
−6
|
3
|
− 6a
|
Urinary increase
|
Urea
|
15
|
12
|
−1
|
12
|
18a
|
15
|
0
|
13
|
32a
|
|
Na
|
52
|
−2
|
95a
|
25
|
33
|
30
|
62a
|
65
|
91a
|
|
Na ex
|
50
|
24
|
125a
|
24
|
50
|
68
|
108a
|
51
|
7
|
|
Cl
|
46
|
5
|
101a
|
14
|
35
|
28
|
67a
|
56
|
94a
|
|
Cl ex
|
51
|
31
|
138a
|
20
|
63
|
70
|
121a
|
48
|
13
|
Urinary decrease
|
Clearance
|
− 20a
|
− 20a
|
−19
|
−4
|
−11
|
−20
|
− 20a
|
− 24a
|
− 40a
|
|
Creatinine
|
−19
|
−37
|
− 36a
|
−5
|
− 32a
|
− 37a
|
−43
|
−23
|
−1
|
|
Creatinine ex
|
−18
|
− 17a
|
−21
|
−5
|
−11
|
− 19a
|
− 21a
|
− 22a
|
− 39a
|
- OPLS-DA was performed on 48 variables at month 15. Here, we show meandifferences (%) of variables (adiscriminant at 99% confidencelevel) indicating kidney parameters of female animals, together with sexhormones. Male kidney pathologies are already illustrated inFigure 1.