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Table 3 Percentage variation of parameters indicating kidney failures of femaleanimals

From: Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize

Discriminant variables GMO 11% GMO 22% GMO 33% GMO 11% + R GMO 22% + R GMO 33% + R R (A) R (B) R (C)
Gonadal hormones Estradiol 5 −2 −25 8 −1 2 −26 73a 39
  Testosterone 56a 17 81 5 −9 27 97a 72a 10
Serum decrease or increase Na −1 4a 6a 2 1 1 −7 0 −3
  Cl −5 −7 6a −1 −2 −2 8a −1 −4
  P −17 18a 20a −6 −11 −13 32a −9 −13
  K 2 −4 0 4 5 10 −4 8 5a
  Ca 2a −2 5a 4 3 3 −6 3 6a
Urinary increase Urea 15 12 −1 12 18a 15 0 13 32a
  Na 52 −2 95a 25 33 30 62a 65 91a
  Na ex 50 24 125a 24 50 68 108a 51 7
  Cl 46 5 101a 14 35 28 67a 56 94a
  Cl ex 51 31 138a 20 63 70 121a 48 13
Urinary decrease Clearance 20a 20a −19 −4 −11 −20 20a 24a 40a
  Creatinine −19 −37 36a −5 32a 37a −43 −23 −1
  Creatinine ex −18 17a −21 −5 −11 19a 21a 22a 39a
  1. OPLS-DA was performed on 48 variables at month 15. Here, we show meandifferences (%) of variables (adiscriminant at 99% confidencelevel) indicating kidney parameters of female animals, together with sexhormones. Male kidney pathologies are already illustrated inFigure 1.