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Table 3 Percentage variation of parameters indicating kidney failures of femaleanimals

From: Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize

Discriminant variables

GMO 11%

GMO 22%

GMO 33%

GMO 11% + R

GMO 22% + R

GMO 33% + R

R (A)

R (B)

R (C)

Gonadal hormones

Estradiol

5

−2

−25

8

−1

2

−26

73a

39

 

Testosterone

56a

17

81

5

−9

27

97a

72a

10

Serum decrease or increase

Na

−1

4a

6a

2

1

1

−7

0

−3

 

Cl

−5

−7

6a

−1

−2

−2

8a

−1

−4

 

P

−17

18a

20a

−6

−11

−13

32a

−9

−13

 

K

2

−4

0

4

5

10

−4

8

5a

 

Ca

2a

−2

5a

4

3

3

−6

3

6a

Urinary increase

Urea

15

12

−1

12

18a

15

0

13

32a

 

Na

52

−2

95a

25

33

30

62a

65

91a

 

Na ex

50

24

125a

24

50

68

108a

51

7

 

Cl

46

5

101a

14

35

28

67a

56

94a

 

Cl ex

51

31

138a

20

63

70

121a

48

13

Urinary decrease

Clearance

20a

20a

−19

−4

−11

−20

20a

24a

40a

 

Creatinine

−19

−37

36a

−5

32a

37a

−43

−23

−1

 

Creatinine ex

−18

17a

−21

−5

−11

19a

21a

22a

39a

  1. OPLS-DA was performed on 48 variables at month 15. Here, we show meandifferences (%) of variables (adiscriminant at 99% confidencelevel) indicating kidney parameters of female animals, together with sexhormones. Male kidney pathologies are already illustrated inFigure 1.