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Environmental Sciences Europe

Table 2 Summary of the most frequent anatomical pathologies observed

From: Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize

Organs and associated pathologies

Controls

GMO 11%

GMO 22%

GMO 33%

R (A)

R (B)

R (C)

GMO 11% + R

GMO 22% + R

GMO 33% + R

Males

          

 Kidneys, CPN

3 (3)

4 (4)

5 (5)

7 (7)

6 (6)

5 (5)

3 (3)

5 (5)

4 (4)

4 (4)

 Liver

2 (2)

5 (4)

11 (7)

8 (6)

11 (5)

9 (7)

6 (5)

5 (4)

7 (4)

6 (5)

 Hepatodigestive tract

6 (5)

10 (6)

13 (7)

9 (6)

23 (9)

16 (8)

9 (5)

9 (6)

13 (6)

11 (7)

Females

          

 Pituitary

9 (6)

23 (9)

20 (8)

8 (5)

22 (8)

16 (7)

13 (7)

19 (9)

9 (4)

19 (7)

 Mammary glands

10 (5)

22 (8)

10 (7)

16 (8)

26(10)

20(10)

18 (9)

17 (8)

16 (8)

15 (9)

 Mammary tumors

8 (5)

15 (7)

10 (7)

15 (8)

20 (9)

16(10)

12 (9)

10 (6)

11 (7)

13 (9)

  1. After the number of pathological abnormalities, the number of rats affectedout of the initial ten is indicated in parentheses. Only marked or severechronic progressive nephropathies (CPN) are listed in male animals,excluding two nephroblastomas in groups consuming GMO 11% and GMO 22% +Roundup. Hepatodigestive pathological signs in males concern the liver,stomach, and small intestine (duodenum, ileum, or jejunum). Pathologicalsigns in liver are mostly congestions, macroscopic spots, and microscopicnecrotic foci. In females, pituitary dysfunctions include adenomas,hyperplasias, and hypertrophies. Mammary fibroadenomas and adenocarcinomasare the major tumors detected; galactoceles and hyperplasias with atypiawere also found and added to the pathological signs in mammary glands.
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