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Table 2 Toxicological data for substances of Table 1 with effect concentrations below 1,000 μg L -1

From: Screening for ecotoxicological effects of antiepileptic drugs in biologically treated waste water originating from an epilepsy ward by Danio rerio embryos

Test

Species

Endpoint (time)

Endpoint

Effect concentration (μg L-1)

Bezafibrate

Mussels

D. polymorpha

LOEC (7 days)

piGST transcript expression

0.236 [9]

Diclofenac

Fish (adult)

O. mykiss

LOEC (28 days)

Cytophathology of the liver, kidney, and gills

1 [10]

Metoprolol

Fish (adult)

O. mykiss

LOEC (28 days)

Cytopathology of the liver

1 [11]

Carbamazepine

Rotoxkit (rotifers)

B. calyciflorus

LOEC (48 h)

Reproduction

754 [12]

Phytoplankton

S. obliquus

EC50 (30 days)

Chlorophyll a synthesis

800 [13]

Crustaceans

G. pulex

LOEC (1.5 h)

Behavior

0.01 (ns) [14]

C. dubia

LOEC (7 days)

Reproduction

100 [12]

Mussels

M. galloprovincialis

LOEC (7 days)

Membrane stability

0.1 [15]

Fish (adult)

D. rerio

LOEC (6 weeks)

Egg production, oocytes, and kidney

0.5 [16]

D. rerio

LOEC (3, 7, and 15 days)

DNA integrity

0.31 [17]

 

C. carpio

LOEC (28 days)

Cytopathology of the kidney

1 [11]

  1. LOEC lowest observed effect concentration, ns not significant.