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Table 3 Modified evaluation criteria/questions concerning endpoints and a summary of the evaluation results.

From: Comparison of four different methods for reliability evaluation of ecotoxicity data: a case study of non-standard test data used in environmental risk assessments of pharmaceutical substances

Evaluation method

Evaluation criteria/question

Type of criteria/mark

Summary of evaluation results

Klimisch et al.

Data on the measured parameters (including definitions).

Recommended

Data is presented but endpoints are not clearly defined in at least two studies.

Durda and Preziosi True

Hypothesis clearly defined for studies where NOEC or LOEC values are identified.

Recommended

The hypothesis is not stated in any of these studies.

 

Endpoints appropriate for hypothesis.

Recommended

Endpoints appropriate for dose-response analyses.

Hobbs et al.

Was the biological endpoint (e.g., immobilization or population growth) stated and refined (10 marks)? Award 5 marks if the biological endpoint is only stated.

0, 5, or 10

Stated in all studies, but not always refined

Schneider et al.

Are the study endpoint(s) and their method(s) of determination clearly described?

Recommended, 0, or 1

Not clearly defined in at least two studies.