Evaluation method | Evaluation criteria/question | Type of criteria/mark | Summary of evaluation results |
---|---|---|---|
Klimisch et al. | Data on the statistical evaluations (including method). | Recommended | Not stated in two studies, results missing for one study. |
Durda and Preziosi | Sufficient sample size/replicates. | Recommended | Not stated in one study, sufficient in all other studies. |
Randomized treatments. | Recommended | Not stated in any of these studies. | |
Independence of observations. | Recommended | Not stated in any of these studies. | |
Appropriate statistical model. | Recommended | Not stated in two studies. | |
Statistically significant responses noted. | Recommended | Not stated in three studies. | |
Hobbs et al. | Was each control and chemical concentration at least duplicated? | 0 or 5 | Not stated in one study, controls not stated in two studies. |
Was an appropriate statistical method or model used to determine the toxicity? | 0 or 4 | Not stated in two studies. | |
For NOEC and LOEC data was the significance level 0.05 or less? or FOR LC and EC data was an estimate of variability provided? | 0 or 4 | Not stated in five studies. | |
Schneider et al. | Is the number of animals per group given? | Mandatory, 0, or 1 | Not stated in one study. |
Are the statistical methods applied for data analysis given and applied in a transparent manner? | Recommended, 0, or 1 | Not stated in three studies. | |
OECD guidelines | Statistical analysis and treatment of data; number of test chambers and replicates; number of embryos per replicate; if ANOVA has been used, the size of the effect which can be detected (e.g., the least significant difference). | Mandatory | The non-standard studies were not evaluated according to the OECD reporting requirements. |