Role of nitrous acid in the association between nitrogen dioxide and asthma symptoms: effect of nitrous acid exposure on specific airway resistance in guinea pigs

Environmental Sciences Europe

Table 2 Change in sRaw for each group over time after exposure to HONO

Weeks of exposure	Group C		Group M		p value^b	Group H		p value^b	ANOVA
Weeks of exposure	n^a	Mean ± SD	n^a	Mean ± SD	p value^b	n^a	Mean ± SD	p value^b	p value^c
1	12	1.24 ± 0.37	12	1.79 ± 0.58	∗ 0.034	12	1.44 ± 0.64	0.565	0.056
2	12	1.44 ± 0.37	12	1.65 ± 0.51	0.395	12	1.78 ± 0.36	0.103	0.157
3	12	1.42 ± 0.37	12	2.16 ± 1.19	0.197	12	2.14 ± 1.45	0.213	0.196
4	12	1.36 ± 0.28	12	2.30 ± 1.04	†0.006	12	2.20 ± 0.66	∗ 0.015	†0.006
5	12	1.44 ± 0.32	12	2.44 ± 0.87	†0.002	12	2.46 ± 0.76	†0.002	†0.001
6	12	1.70 ± 0.21	12	2.47 ± 1.22	0.067	12	2.59 ± 0.85	∗ 0.031	∗ 0.035
7	12	1.63 ± 0.22	12	2.27 ± 0.83	∗ 0.028	12	2.19 ± 0.63	0.058	∗ 0.030

Data are presented as the mean ± SD (cmH₂O × mL/(mL/s)) for Experiments 1 and 2. Dunnett's multiple comparison was applied for comparison with the control following ANOVA
^aNumber of animals
^bP value for comparison with the control
^cP value for ANOVA
^* p < 0.05
^†p < 0.01