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Fig. 1 | Environmental Sciences Europe

Fig. 1

From: Introducing oxygen transfer rate measurements as a novel method for time-resolved cytotoxicity assessment in shake flasks

Fig. 1

Oxygen transfer rate (OTR) of CHO cell line one upon addition of ZnCl2 or CoCl2 with and without medium exchange. A Cells were cultured without addition of test substance (closed black triangles), with addition of 0.1 mM ZnCl2 (closed yellow squares) or with addition of 0.2 mM CoCl2 (blue circles). Test substances were added at the beginning of the cultivation (t = 0 h). B Cells were cultured without addition of test substance (closed black triangles), with addition of 0.1 mM ZnCl2 (closed orange squares) or with addition of 0.2 mM CoCl2 (open cyan circles). After 24 h (black arrow), medium was exchanged by fresh culture medium without a test substance added. Data from experiment 1 (see Additional file 1: Table S1)

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