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Table 2 In vitro and in vivo chlorophyll measurements for nanoparticles and microparticles, focusing on ErC50 values and the degree of inhibition relative to the control at each test concentration

From: Testing particles using the algal growth inhibition test (OECD 201): the suitability of in vivo chlorophyll fluorescence measurements

Material Method ErC50
[mg/L]a
Effect [%]b
0.1 1 10 100
Fibers
Cu In vitro 0.16 [0.07–0.34] 39 88 100 100
In vivo 0.28 [0.19–0.42] 28 76 100 100
TiO2_fibers In vitro 1.3 [n.d.]b 10 29 100 100
In vivo 1.9 [0.7–5.1] 12 35 82 85
SiC_thin In vitro 99.9 [29.1–315.6] − 7 − 4 9 48
In vivo 89.4 [45.3–169.5] − 2 4 12 53
Platelets
Ag—ES-4 In vitro 10–100 12.4 2.5 − 0.6 100
In vivo 10–100 0.1 3.9 − 1.0 100
Spheres / compact particles
PMMA In vitro No effect n.i.c − 4.9 − 1.7 − 4.8
In vivo No effect n.i.c 1.7 6.2 2.7
PE_broad_
distribution
In vitro No effect n.i.c n.i.c 24.1 47.2
In vivo No effect n.i.c n.i.c 15.5 41.4
PA-6 In vitro No effect n.i.c n.i.c − 4.8 − 6.0
In vivo No effect n.i.c n.i.c − 3.7 − 4.4
IN718 In vitro No effect 27.9 23.5 27.0 21.2
In vivo No effect 20.3 18.4 22.0 16.2
Ti64 In vitro No effect − 0.1 16.5 − 0.9 − 6.5
In vivo No effect 1.0 4.6 1.4 − 1.5
IN-Y2O3 In vitro No effect n.i.c − 13.3 − 7.3 − 22.0
In vivo No effect n.i.c − 12.9 − 5.9 − 16.6
Ti64-SiC In vitro No effect 1.0 − 3.9 − 13.9 − 15.3
In vivo No effect − 1.7 − 2.3 − 6.1 − 2.5
  1. aDue to the dilution factor of 10, the ErC50 value is just a proxy for a rough assessment of ecotoxicity; values in square brackets represent confidence intervals. bMean inhibitory effect at various test concentrations; n.d. = not determinable for mathematical reasons. cn.i. = not investigated