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Fig. 5 | Environmental Sciences Europe

Fig. 5

From: Effects of subchronic exposure of nonylphenol on the expression of immune-related factors and estrogen receptors in the spleen of rats

Fig. 5

RNA-Seq to analyze the changes of related immune cytokines in the spleen. A Correlation analysis chart of differential gene expression. B Bubble chart of pathway analysis of differential gene signal of down-regulation. C Heat map of immune-related differential cytokines. D Volcano map of differential gene expression. E Bubble chart of pathway analysis of up-regulated differential gene signal. F Three-dimensional image of screening of related immune cytokines. G NF-κB signal pathway diagram. H Toll-like receptor signal pathway diagram (A represented the blank control, D represented the 40 mg/kg NP group). In the figure, the blue dashed box was the down-regulated significance mark, and the red dashed box was the up-regulated significance mark. log2FoldChange: the multiple of the difference of log2, the value of this study was greater than 2 times or less than 0.5 times, P value: indicating the level of significance. Padj: P value correction value; Gene symbol: gene name; IL1R: IL1 receptor; TLR2: toll-like receptor; INOS: inducible nitric oxide synthase; IL1β: interleukin-1 beta; EGF: fibroblast growth factor; TNF-a: TNF-alpha; CXCL4: Chemokine (C–X–C motif) ligand 4; TLR4: toll-like receptor-4; MKK3/6: mitogen-activated protein Kinase Kinase 3/6; TGF-α: transforming growth factor alpha; CSF: colony-stimulating factor; BMP: bone morphogenetic protein; HGF: hepatocyte growth factor; LIF: leukemia inhibitory factor; NGF: nerve growth factor; IAP: inhibitor of apoptosis proteins; XIAP: X-linked inhibitor of apoptosis proteins

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