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Table 3 Distribution of EC10 lower bound (ECL10) estimates for shape ECPB  =  1

From: Statistical analysis of avian reproduction studies

ECL10

Percentiles

   

Mean

Med

10

25

75

90

YMAX

CV

ECPB

20

20

17

18

22

24

60

5

1

15

15

9

12

18

21

60

10

1

7

7

−1

2

11

16

60

20

1

0

0

−9

−4

5

10

60

30

1

−7

−4

−21

−9

1

5

60

40

1

29

29

23

26

32

35

70

5

1

21

21

11

17

26

31

70

10

1

7

9

−6

−1

14

22

70

20

1

−33

−3

−22

−11

5

10

70

30

1

−29

−9

−47

−18

−2

3

70

40

1

42

42

34

38

47

50

80

5

1

29

30

11

22

37

45

80

10

1

−29

6

−29

−11

15

23

80

20

1

−73

−10

−94

−31

0

8

80

30

1

−115

−16

−132

−46

−5

0

80

40

1

54

68

36

58

77

83

90

5

1

−87

28

−155

−10

45

58

90

10

1

−285

−29

−574

−129

−3

14

90

20

1

−269

−41

−664

−123

−11

0

90

30

1

  1. ECL10: Mean = mean ECL10 estimate from simulated data; ECL10: Med = median ECL10 estimate from simulated data; Percentiles: = percentile of ECL10 estimates from simulated data, N = 10, 25, 75, 90; YMAX = maximum % of control mean response at highest concentration in simulated data; CV = coefficient of variation simulated (%); ECPB = shape parameter controlling the shape of the simulated curve; a negative mean or median ECL10 or another percentile indicate ECL10 estimate of little value for risk assessment. When ECL10<0 then the EC10 estimate is statistically indistinguishable from zero