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Table 2 Distribution of EC10 point estimates for shape ECPB  =  1

From: Statistical analysis of avian reproduction studies

EC10

Percentiles

YMAX

CV

ECPB

%Fit

P90/P10

Mean

Med

10

25

75

90

26

26

22

23

28

30

60

5

1

100

1.4

26

25

18

21

30

34

60

10

1

100

1.8

25

24

13

17

32

38

60

20

1

87

2.9

24

23

10

14

32

41

60

30

1

50

4.1

63

21

7

12

33

46

60

40

1

26

6.6

37

37

31

33

41

43

70

5

1

100

1.4

36

35

26

30

42

47

70

10

1

100

1.8

34

33

17

23

44

55

70

20

1

73

3.2

36

30

11

18

45

60

70

30

1

40

5.4

68

27

7

14

45

61

70

40

1

18

9.0

55

55

46

50

60

64

80

5

1

100

1.4

53

53

38

44

62

70

80

10

1

99

1.8

68

48

22

33

64

77

80

20

1

57

3.5

70

39

12

23

60

81

80

30

1

24

6.7

56

35

5

16

58

89

80

40

1

8

17.6

100

96

83

89

106

122

90

5

1

97

1.5

150

92

63

77

118

207

90

10

1

77

3.3

246

77

30

50

131

341

90

20

1

48

11.3

162

60

8

27

94

219

90

30

1

35

28.4

139

48

0

15

84

251

90

40

1

24

5410.5

  1. EC10: Mean=mean EC10 estimate from simulated data; EC10: Med=median EC10 estimate from simulated data; Percentiles: =percentile of EC10 estimates from simulated data, N=10, 25, 75, 90; YMAX=maximum % of control mean response at highest concentration in simulated data; CV=coefficient of variation simulated (%); %Fit=Percent of simulated datasets for which at least one model converged and had a positive lower confidence bound for EC10 estimate; P90/P10=ratio of the indicated percentiles of the distribution of EC10 estimates. Larger values indicate more spread in the point estimates; ECPB=shape parameter controlling the shape of the simulated curve