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Environmental Sciences Europe
Fig. 1 | Environmental Sciences Europe

Fig. 1

From: Synthesis of typical sulfonamide antibiotics with [14C]- and [13C]-labeling on the phenyl ring for use in environmental studies

Fig. 1

Synthetic pathways of [14C]- and [13C]-labeled SMX (5a, 5b), [14C]- and [13C]-labeled SMM (7a, 7b), and [14C]- and [13C]-labeled SDZ (10a, 10b). I Method: ClSO3H + NaCl in CCl4, 58 °C; purification by flash column chromatography. II Method: ClSO3H + SOCl2 in CCl4, 58 °C; without purification. Yields% (c) and purities% (d) of the synthesized [14C]- or [13C]-labeled compounds are provided. The radiochemical purity of the [14C]-labeled intermediates and [14C]-labeled SAs was determined by TLC coupled to autoradiography and by HPLC coupled to LSC, respectively. The chemical purity of the [13C]-labeled intermediates and SAs was determined by HPLC

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