From: An efficient and pragmatic approach for regulatory aquatic mixture risk assessment of pesticides
Mixture risk assessment components | EFSA [14] | Chen et al. [8] |
---|---|---|
Screening stage | No screening stage included in the decision scheme | Tier 0 screening stage focussing on single a.s. analyses |
Selection of suitable exposure scenario | Required to conduct the entire risk assessment scheme for every exposure scenario separately | Use of worst-case PECs from all exposure scenarios to create one worst-case exposure scenario |
Identification of substances which drive the exposure or risk assessment | Toxicity driver approach using the concept of TUs | No toxicity or risk driver evaluated |
Measured mixture toxicity data | Not strictly required | Required after screening stage |
Default assumption for calculated mixture toxicity | CA (use of IA possible under certain conditions) | CA (use of IA possible under certain conditions) |
Comparison of measured and calculated mixture toxicity | MDR (not required if no measured data available) | MDR (required after screening stage) |
Risk assessment | Based on ETR (use of RQ possible under certain conditions) | Based on RQ |