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Table 2 Comparison of mixture risk assessment components in EFSA [13] and Chen et al. [8]

From: An efficient and pragmatic approach for regulatory aquatic mixture risk assessment of pesticides

Mixture risk assessment components

EFSA [14]

Chen et al. [8]

Screening stage

No screening stage included in the decision scheme

Tier 0 screening stage focussing on single a.s. analyses

Selection of suitable exposure scenario

Required to conduct the entire risk assessment scheme for every exposure scenario separately

Use of worst-case PECs from all exposure scenarios to create one worst-case exposure scenario

Identification of substances which drive the exposure or risk assessment

Toxicity driver approach using the concept of TUs

No toxicity or risk driver evaluated

Measured mixture toxicity data

Not strictly required

Required after screening stage

Default assumption for calculated mixture toxicity

CA (use of IA possible under certain conditions)

CA (use of IA possible under certain conditions)

Comparison of measured and calculated mixture toxicity

MDR (not required if no measured data available)

MDR (required after screening stage)

Risk assessment

Based on ETR (use of RQ possible under certain conditions)

Based on RQ