Fig. 1From: Approaches, limitations and challenges in development of biomarker-based strategy for impact assessment of neuroactive compounds in the aquatic environmentSelection of specific biomarkers, identification, confirmation and validation of biomarker’s response patterns for impact assessment of neuroactive compounds in the aquatic environment: synchronization of mechanistic and field studies and integration into AOP framework. NCs neuroactive compounds, LoE line of evidence, CBM component-based predictive mixture modeling, EBM effect-based methods (bioanalytical tools)Back to article page