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Table 6 Factors included in the PECsoil initial calculation and their relationship with the result (positive correlation, negative correlation, constant factor, and factor neglected in the respective equation), the summarized trends in animal husbandry, and the expected effect on PECsoil initial

From: Critical discussion of the current environmental risk assessment (ERA) of veterinary medicinal products (VMPs) in the European Union, considering changes in animal husbandry

Factors

Equations for PECsoil initial calculation, according to EMA [22] and as shown in Additional file 1: Table S1a

Changes in animal husbandry in the last decade

Expected effect on PECsoil initialb

 

Intensively reared animals

Pasture animals

Dairy cattle teat dips or sprays

  

Numerator

     

Daily dose of the active ingredient (a.i.)

/

/

Low dosec

Number of days of treatment

/

/

One shotc

Average body weight

/

Increased for some animal types

Maximum body weight

/

Increased for some animal types

Animal turnover rate per place per year

/

Decreases or remains constant

Stocking density

/

Decreases or remains constant

EU nitrogen spreading limit

°

Remains constant

°

Fraction of herd treatment

/

/

Decreases for many product groups

Volume of dip used each milking

/

Decreases or disappears completely (antibiotics), while other remain constantd

Number of milkings per day

/

Increases slightlye

Number of days a dairy cow is in lactation

°

Remains constant

°

Concentration of the a.i. in the product

/

No or unknown evidence for changes

°

Fraction of dip entering dirty water

/

Remains constant

°

Denominator

     

Bulk density of dry soil

°

°

°

Remains constant

°

Depth of penetration into soil

°

°

°

Remains constant

°

N produced per year per place

\

Increased for some animal types

Housing factor

\

Remains constant

°

Spreading rate for dirty water

°

Remains constant

°

Volume of water used to wash the milking parlor

°

Remains constant

°

  1. a/, Positive correlation; \, negative correlation; °, constant factor; –, factor neglected in the respective equation
  2. b↑, Increase; ↓, decrease; °, constant
  3. cData indicating these changes [147,148,149]
  4. dData indicating these changes [150, 151]
  5. eData indicating these changes [152, 153]