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Environmental Sciences Europe

Table 2 Human AChE (hAChE) inhibitory concentration 50 (IC50) of the tested compounds

From: Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment

Compound

hAChE IC50 [nM]

1

4.3 ± 0.4

2

4.8 ± 0.7

3

6.9 ± 0.8

4

11.6 ± 0.9

5

5.9 ± 0.3

6

2.6 ± 0.2

7

16.8 ± 2.2

8

4.9 ± 0.4

9

7.2 ± 0.8

10

2.2 ± 0.5

Huprine Y

1.1 ± 0.1

  1. Paraoxon’s IC50 cannot be directly determined due to the irreversibility of the inhibition. According to Rosenfeld and Sultatos [30], paraoxon’s inhibition constant ki in human recombinant acetylcholinesterase is 0.125–0.180 nM−1 h−1 (24–37 °C)
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