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Table 1 List of chemicals used in this study

From: Mixture toxicity analysis in zebrafish embryo: a time and concentration resolved study on mixture effect predictivity

Substance

Structure

CAS RN

Usage/origin

Mode of action

Toxic ratio

Benzo[a]pyrene

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50-32-8

PAH, incomplete burning

Epoxide reacts with DNA and produces carcinogenic adduct

*

Benzo[b]fluoranthene

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205-99-2

PAH, incomplete burning

Mutagenic

*

Bisphenol A

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80-05-7

Polymer synthesis

Binding to estrogen-related receptors

5.18E−01

Carbendazim

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10605-21-7

Fungicide

Inhibitor of mitosis and cell division

1.51E+03

Chlorophene

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120-32-1

Antiseptic drug, disinfectant

Unknown

1.94E+00

Cyprodinil

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121552-61-2

Fungicide

Inhibition of methionine biosynthesis

9.34E+00

Diazinon

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333-41-5

Insecticide

Inhibition of acetylcholinesterase

8.17E−01

Diclofenac sodium salt

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15307-79-6

Pharmaceutical

Inhibition of cyclooxygenase I and II, non-steroidal anti-inflammatory drug (NSAID)

6.54E+02

Diuron

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330-54-1

Herbicide

Inhibition of photosynthesis: blocking of plastoquinone binding site of PSII

5.40E+03

Genistein

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446-72-0

Antineoplastic agent

Inhibition of protein-tyrosine kinase and topoisomerase II: induction of G2-phase arrest in human and mice

2.21E+02

Naphthalene

91-20-3

Industry, insecticide

Epoxide induces hemolysis, induces narcosis

1.20E+00

Naproxen sodium salt

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26159-34-2

Pharmaceutical

Inhibition of cyclooxygenase I and II, non-steroidal anti-inflammatory drug (NSAID)

1.09E+02

Propiconazole

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60207-90-1

Fungicide

Inhibition of ergosterol biosynthesis

5.34E−01

Triclosan

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3380-34-5

Anti-infective agent, antiseptic drug, disinfectant

Binding of bacterial enoyl-acyl carrier protein reductase enzyme

8.85E−01

Triphenyl phosphate

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115-86-6

Flame retardant, plasticizer

Neurotoxicity, developmental toxicity, metabolic disruption, endocrine activity, genotoxicity and estrogenic activity

1.56E+00

  1. *No toxicity observed at measured concentrations