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Table 2 Summary of morphological alterations in zebrafish (Danio rerio) embryos after 96 or 120/144 h exposure

From: Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

  1. The four core endpoints listed by OECD TG 236 (OECD, 2013) are indicated in bold. Frequency of occurrence:   —frequent and/or at concentrations < LC10; — ≤ 20% of exposed organisms and/or only at concentrations > LC10; —not observed for this compound
  2. * Additional determination at 120 and/or 144 hpf (cf. Table 1); # no symptoms of acute lethality at highest solubility in a final DMSO concentration of 1 %; $ no differentiation for specific spinal cord deformations; endpoints grouped under general “spinal cord malformation”