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Table 1 Acute and sublethal toxicity data from the fish embryo tests with zebrafish (Danio rerio) as computed by ToxRat™

From: Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

  n Toxicity 96 h (mg/L)  Toxicity 120 h (mg/L)/144 h (mg/L)a
EC10 EC50 LC10 LC50 EC10 EC50 LC10 LC50
Acrylamide 4 75.400 94.000 166.600 199.300     
Carbamazepine 3 42.700 81.330 138.760 164.920 53.400 62.600 124.500 147.400
Carbaryl 2 2.200 2.400 6.600 12.200     
Clofibrate 2 200.000 300.000 600.000 1100.000     
Colchicine 4 23.100 32.400 32.500 41.400     
Copper (II) sulphate 3 0.400 0.700 0.600 0.800 0.200 0.600 0.600 0.800
Dibutyl maleate 3 0.400 0.600 0.500 0.700     
3,4-Dichloroaniline 3 1.200 1.900 1.600 2.400     
Dimethyl sulfoxide 3 14,460.000 20,100.000 27,200.000 36,560.000 20,250.000 24,610.000 25,390.000 33,880.000
2,2-Dimethylvaleric acid 2 56.600 64.300 71.700 77.200 54.400 62.500 71.700 77.200
Dinitro-o-cresol 3 0.300 0.400 0.400 0.500 0.300 0.400 0.400 0.500
2,4-Dinitrophenol 3 2.000 2.700 3.400 4.100 1.600 2.400 2.000 2.700
Ethanol 3 5800.00 7840.000 8650.000 11,3000.000     
2-Ethylbutyric acid 3 20.100 47.100 68.500 95.700 32.300 58.300 61.200 83.700
2-Ethylhexanoic acid 3 5.600 20.800 24.200 40.000 7.200 16.400 24.200 38.200
Hexachlorophene 2 0.004 0.005 0.007 0.008     
Hexanoic acid 2 62.500 69.400 75.300 76.100 61.900 67.000 74.600 77.200
Ibuprofen 2 4.700 10.800 31.700 37.300     
Luviquat 3 0.300 0.500 0.400 0.900 0.400 0.600 0.300 0.800
Malathion 3 0.800 1.200 2.800 3.500 0.800 1.100 2.000 2.600
Merquat 3 0.200 0.300 0.300 0.500 0.200 0.300 0.200 0.500
2-Methylhexanoic acid 2 46.500 53.900 75.200 84.100 28.700 42.600 75.300 84.100
6-Methyl-5-heptene-2-one 3 54.500 81.700 76.100 139.700     
Methylmercury (II) chloride 3 0.020 0.030 0.030 0.040 0.0100 0.020 0.030 0.030
2-Methylpentanoic acid 3 35.900 53.500 59.800 77.000 43.200 54.400 52.300 67.800
1-Methyl-4-phenyl-pyridinium iodide 3 No effects observable up to solubility limits (up to 1% final DMSO concentration)b
1-Octanol 3 8.700 12.400 13.700 18.900 10.100 15.100 13.200 18.400
Paracetamol 2 200.000 300.000 1000.000 1200.000     
Paraquat 2 328.700 353.200 933.800 1161.400 384.700 545.900 721.100 855.000
4-Pentenoic acid 2 52.100 60.200 90.800 107.100 52.200 60.100 63.500 103.500
PCB 180 3 No effects observable up to solubility limits (up to 1% final DMSO concentration)b
Prochloraz 3 1.700 3.800 2.300 4.500 1.500 3.200 2.200 4.300
2-Propylheptanoic acid 3 3.400 4.100 10.000 13.500 2.400 3.100 8.900 11.500
Rifampicin 3 No effects observable up to solubility limits (up to 1% final DMSO concentration)b
Rotenone 2 0.004 0.007 0.006 0.010     
Sodium chloride 3 1090.00 3370.000 2860.000 5910.000     
Sodium tetradecyl sulphate 3 0.300 0.300 0.300 0.300 0.200 0.300 0.300 0.300
Sulfisoxazole 3 No effects observable up to solubility limits (up to 1% final DMSO concentration)b
Taxol 3 No effects observable up to solubility limits (up to 1% final DMSO concentration)b
Tebuconazole 2 2.300 5.300 15.000 17.300     
Tolbutamide 2 54.300 116.900 223.200 278.600     
Triclosan 3 0.100 0.200 0.200 0.300     
Triethylene glycol 3 31,220.000 35,700.000 45,220.000 54,220.000 26,400.000 32,300.000 45,000.000 52,200.000
2,3,6-Trimethyl phenol 3 9.800 12.300 10.500 14.100     
Triphenylphosphate 2 0.300 0.500 1.400 1.600     
4-ene-Valproic acid 2 24.700 37.400 41.900 56.100 28.400 33.100 49.800 68.900
Valproic acid 3 3.100 9.100 26.200 56.900 6.200 11.800 33.300 62.700
Zinc pyrithione 3 0.002 0.005 LC > solubility limits      
  1. Date are given as mean ± SD from n independent replicates
  2. aData for 144 h in italics
  3. bFor data on solubility limits, see Additional file 1: Table S2