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Fig. 6 | Environmental Sciences Europe

Fig. 6

From: Adverse effects in the fish embryo acute toxicity (FET) test: a catalogue of unspecific morphological changes versus more specific effects in zebrafish (Danio rerio) embryos

Fig. 6

Overview of three out of the four core endpoints of acute lethality prescribed by OECD TG 236 (OECD 2013) in zebrafish (Danio rerio) embryos after exposure to various chemicals. a Gastrulation arrest after 24 hpf caused by 16 mg/L hexachlorophene. b Coagulation of a fertilised embryo after 24 hpf caused by 4 mg/L 3,4-dichloroaniline. c Late coagulation at 9 hpf caused by 40 µg/L colchicine. d Slightly reduced detachment of the tail after 24 hpf caused by 9 mg/L 2-propylheptanoic acid. e Barely detached tail after 24 hpf caused by 116 mg/L 2-ethylbutyric acid. f Complete lack of tail detachment after 24 hpf caused by 43 mg/L 2-propylheptanoic acid. g Reduced somite formation (dM) caused by 15 mg/L carbaryl exposure. h Fracturing of the notochord (F) and reduced somite formation (dM) caused by 7 mg/L 2-methylpentanoic acid. The fourth core endpoint, lack of heart beat, cannot be documented in static micrographs

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