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Table 2 The regression coefficients (α and β in the Weibull function), fitting statistics (R2 and RMSE), and pEC50 values of nine mixture rays on MTL-2 at 12 and 24 h

From: Genetically modified Caenorhabditis elegans may lead to inaccurate toxicity evaluation of mixtures

Mixture ray

Time (h)

Emax,exp

α

β

R2

RMSE

PEC50

PEC*50

SM-R1

12

0.7778

9.70

3.59

0.9819

0.0349

2.804

2.294

24

0.9892

10.04

3.31

0.9758

0.0555

3.144

2.559

SM-R2

12

0.9167

7.10

2.36

0.9725

0.0522

3.164

2.193

24

1.0000

7.10

2.36

0.9703

0.0577

3.321

2.401

SM-R3

12

0.7500

5.69

2.02

0.9654

0.0501

2.998

2.111

24

0.9375

6.22

1.95

0.9652

0.0576

3.378

2.408

SM-R4

12

0.7083

7.58

2.89

0.9920

0.0184

2.750

2.018

24

0.9583

8.46

2.84

0.9949

0.0230

3.108

2.277

SM-R5

12

0.6667

7.33

2.82

0.9776

0.0305

2.729

2.263

24

1.0000

9.60

3.14

0.9960

0.0224

3.174

2.578

SM-R6

12

0.7059

7.76

2.91

0.9776

0.0340

2.793

2.134

24

1.0000

8.37

2.65

0.9933

0.0306

3.297

2.417

SM-R7

12

0.7500

4.68

1.67

0.9558

0.0556

3.022

2.156

24

1.0000

6.77

2.10

0.9924

0.0299

3.398

2.407

SM-R8

12

0.8125

5.15

1.76

0.9638

0.0567

3.134

–

24

1.0000

5.77

1.72

0.9778

0.0499

3.568

2.354

SM-R9

12

0.7692

4.84

1.67

0.9581

0.0594

3.118

2.116

24

1.0000

5.92

1.80

0.9877

0.0372

3.493

2.318

  1. The values of pEC50 of nine mixture rays on N2 (Li et al. [35])