Testing for | Biotest used | According to |
---|---|---|
Genotoxicity | Ames-fluctuation test | ISO 11350 guideline, described in detail by Giebner et al. [37] |
SOS Chromotest | White et al. [38] | |
Dioxin-like toxicity | Reporter gene assay with H4IIE-luc-cells | Garrison et al. [39], described in detail by Maier et al. [32] |
Yeast Dioxin Screen | Stalter et al. [40] | |
(Anti-) Oestrogenicity | Y(A)ES | Stalter et al. [40], described in detail by Giebner et al. [37] |
E-Screen | Lange et al. [41] | |
Reporter gene assay with HeLA cells | ||
(Anti-) Androgenicity | Y(A)AS | Stalter et al. [40], described in detail by Giebner et al. [37] |
Reporter gene assay with MDA-kb2-cells | Wilson et al. [44] | |
Phytotoxicity | Lemna minor growth inhibition test | OECD 221 [45] |
Embryo- and developmental toxicity | Fish embryo acute toxicity test (FET) with Danio rerio | |
Effects on reproduction | Sediment and water toxicity test with Lumbriculus variegatus | OECD 225 [48] |
Potamopyrgus antipodarum reproduction test | OECD 242 [49], described in detail by Giebner et al. [37] and Henneberg et al. [43] |