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Fig. 4 | Environmental Sciences Europe

Fig. 4

From: Diuron modulates the DNA methylation status of the ILT7 and TRAIL/TNFSF10 genes and decreases the killing activity of plasmacytoid dendritic cells

Fig. 4

The Diuron-mediated decreased killing activity of pDC is associated with the modulation of the methylation status of ILT7 and TRAIL. a Graph illustrates the Diuron-induced fold change of mRNA expression encoding for molecular actors of killing pDC activity and shows an increase of ILT7 and a decrease of TRAIL expression. b Graph illustrates the Diuron-induced fold change of ILT7 (In-cell ELISA, Abcam, France) and TRAIL (ELISA, Abcam, France) expression at protein level. The ILT7 signal was normalized by total cell numbers using Janus Green, a whole cell stain. c Graph illustrates the percentage of DNA methylation of the ILT7 and TRAIL promoters. Diuron exposure induced a decrease of both. d Graph illustrates the Diuron-induced increasing of CTCF enrichment on the TRAIL promoter

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