AOP number | AOP name (as of June 2018) | Status of AOP (as of June 2018) | Snapshotb | ||
---|---|---|---|---|---|
SAAOP status | OECD status | URL | Date (MM.DD.YYY) | ||
8 | Upregulation of thyroid hormone catabolism via activation of hepatic nuclear receptors, and subsequent adverse neurodevelopmental outcomes in mammals short | Included in OECD work plan | Under development | 01.04.2019 | |
18 | PPARα activation in utero leading to impaired fertility in males | Included in OECD work plan | EAGMST under review | 01.04.2019 | |
29a | Estrogen receptor agonism leading to reproductive dysfunction | Under development | – | 01.04.2019 | |
51 | PPARα activation leading to impaired fertility in adult male rodents | Included in OECD work plan | Under development | 01.04.2019 | |
64 | Glucocorticoid receptor (GR) mediated adult Leydig cell dysfunction leading to decreased male fertility | Under development | _ | 01.04.2019 | |
71 | Modulation of adult Leydig cell function subsequent to glucocorticoid activation | Under development | _ | 01.04.2019 | |
124 | HMG-CoA reductase inhibition leading to decreased fertility | Under development | _ | 01.04.2019 | |
144 | Lysosomal damage leading to liver inflammation | Included in OECD work plan | Under development | 20.12.2016 | |
152 | Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity | Included in OECD work plan | Under development | 01.04.2019 | |
163 | PPARgamma activation leading to sarcomas in rats, mice, and hamsters | Under development | _ | 01.04.2019 | |
200 | Estrogen receptor activation leading to breast cancer | Under development | _ | 01.04.2019 | |
220 | Chronic Cyp2E1 activation leading to liver cancer | Included in OECD work plan | EAGMST under review | 17.11.2017 |