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Table 4 Plausible AOPs for category I flame retardants

From: Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

AOP number

AOP name (as of June 2018)

Status of AOP (as of June 2018)

Snapshotb

SAAOP status

OECD status

URL

Date (MM.DD.YYY)

8

Upregulation of thyroid hormone catabolism via activation of hepatic nuclear receptors, and subsequent adverse neurodevelopmental outcomes in mammals short

Included in OECD work plan

Under development

https://tinyurl.com/y9c4kh4v

01.04.2019

18

PPARα activation in utero leading to impaired fertility in males

Included in OECD work plan

EAGMST under review

https://tinyurl.com/yb8qwyro

01.04.2019

29a

Estrogen receptor agonism leading to reproductive dysfunction

Under development

https://tinyurl.com/y8hd6hnd

01.04.2019

51

PPARα activation leading to impaired fertility in adult male rodents

Included in OECD work plan

Under development

https://tinyurl.com/yahpasof

01.04.2019

64

Glucocorticoid receptor (GR) mediated adult Leydig cell dysfunction leading to decreased male fertility

Under development

_

https://tinyurl.com/ybjes6b8

01.04.2019

71

Modulation of adult Leydig cell function subsequent to glucocorticoid activation

Under development

_

https://tinyurl.com/ya3wbsve

01.04.2019

124

HMG-CoA reductase inhibition leading to decreased fertility

Under development

_

https://tinyurl.com/ycudbwgf

01.04.2019

144

Lysosomal damage leading to liver inflammation

Included in OECD work plan

Under development

https://tinyurl.com/yb7yu9fo

20.12.2016

152

Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity

Included in OECD work plan

Under development

https://tinyurl.com/yd6wzrbm

01.04.2019

163

PPARgamma activation leading to sarcomas in rats, mice, and hamsters

Under development

_

https://tinyurl.com/y9k2wmln

01.04.2019

200

Estrogen receptor activation leading to breast cancer

Under development

_

https://tinyurl.com/yat8frjl

01.04.2019

220

Chronic Cyp2E1 activation leading to liver cancer

Included in OECD work plan

EAGMST under review

https://tinyurl.com/y8qvefdm

17.11.2017

  1. AOP Status (extracted from the Users’ handbook [48]): SAAOP status (Society for the Advancement of AOPs): “Under development”—content still under development, not ready for formal review; “Included in OECD work plan”—an AOP development project has been reviewed, accepted into the OECD workplan, and the project number assigned. OECD status—reflects the progress after the AOP has been included in the OECD AOP Development Workplan. (OECD—Organisation for Economic Co-operation and Development; EAGMST—Advisory Group on Molecular Screening and Toxicogenomics)
  2. aApplicability domain for AOP 29 is fishes and amphibians
  3. bSnapshot representing the state of the AOP at the time when the data was collected for the Snapshot