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Table 3 Potential molecular targets (“verified hits”) identified in ToxCast assays

From: Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

  1. Color code indicates to which target the assay is related: bright blue—PXR; dark blue—other related to drug metabolism; orange—VDR; red—PPAR; green—TSPO; purple—AR; yellow—various unique targets
  2. “Verified hit”: AC50 ≤ 10 µM or AC50 ≤ 1 µM (if cytotoxicity limit is close to, or bellow, 10 µM), and verified after examining the dose–response curve
  3. PXR pregnane X receptor, CYP2C19 cytochrome P450 family 2 subfamily C polypeptide 19, PPAR peroxisome proliferator-activated receptor, VDR vitamin D receptor, ER1 estrogen receptor 1, TSPO translocator protein, AR androgen receptor, MMP(mit) mitochondrial membrane potential, GR glucocorticoid receptor, RXRβ retinoid X receptor beta, uPAR urokinase receptor, MMP(met)1 matrix metallopeptidase 1, PAI plasminogen activator inhibitor, NR1I3 nuclear receptor subfamily 1 group I member 3
  4. aMMP abbreviation is used for two different names in ToxCast: mitochondrial membrane potential (we added “(mit)”) and matrix metallopeptidase (we added “(met)”)