Fig. 1

Schematic presentation of the procedure for linking toxicological data on Category I FRs to existing AOPs and select plausible AOPs, an example for TDCIPP. The 3 main steps of the procedure are detailed and illustrated with extracts from Excel tables (a, b) and pivot tables (c) generated from the table shown in b. Full data corresponding to table shown in a are presented in Additional file 4: Tables S5. Schemes on the right illustrate the goal of steps A and B (linking evidence from literature to individual MIE/KE/AO and corresponding AOPs), and then c (selecting plausible AOPs). Plain arrows indicate that some supporting evidence links the chemical to the MIE/KE/AO and the thickness of the arrow refers to the weight of evidence and level of toxicity