Table 1 The different endpoints observed along the 105-h exposure in Danio rerio embryos, their associated mode of action and major classes of contaminants associated

Modulation of heart rate

48

Cardiotoxicity: Decrease (bradycardia) or increase (tachycardia) of the heartrate. Blocks of the β-adrenergic receptor, mainly on the myocardium

Carlsson et al. [73]

Fraysse, Mons and Garric [25]

Mainly β-blockers (i.e., propranolol, metoprolol), PPCPs, several insecticides

Delayed hatching

From 72 to 96

Inhibition of high choriolytic enzymes and physical movement of the embryo

Jin et al. [74]

De Gaspar et al. [75]

Several inorganic and organic pollutants

Inhibition of locomotor activity

96

Neurotoxicity: decrease or increase of the swimming distance and dark/light stimulation

Irons et al. [76] Selderslaghs et al. [77]

Several neuroactive pollutants

Inhibition of AChE activity

105

Neurotoxicity: inhibition of the acetylcholisterase and increase of the duration of action of neurotransmitter acetylcholine

Küster [39]

Strmac et al. [78]

Kais Stengel, Batel and Braunbeck [9]

Organophosphates and carbamates insecticides, organophosphates flame retardants (OPFR), polycyclic aromatic hydrocarbons (PAHs)

Sublethal and mortality effects

From 24 to 105

Embryotoxicity and teratogenicity

Scholz et al. [79]

Several inorganic and organic pollutants