|
Malformation rate (%)
|
---|
July 15
|
November 15
|
January 16–April 16
|
July 16
|
---|
Control (N)
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
N1
|
2.42
|
0
|
7.14*
|
15.52*
|
12.10*
|
16.67*
|
2.0
|
12.10*
|
0.93
|
1.19
|
10.48*
|
0
|
N2
|
3.13
|
0
|
5.36*
|
3.57
|
7.26*
|
8.62*
|
1.85
|
0
|
0
|
15.74*
|
9.68*
|
1.56
|
N3
|
10.15
|
4.03
|
9.38*
|
6.25*
|
0.86
|
6.25*
|
9.00*
|
9.68*
|
1.67
|
11.11*
|
0
|
3.13
|
N4
|
0
|
2.34
|
0
|
3.91
|
2.68
|
0.83
|
9.52*
|
0
|
0.78
|
1.61
|
0.78
|
0
|
N5
|
0
|
0
|
3.23
|
7.03*
|
2.50
|
1.61
|
4.46
|
3.45
|
1.72
|
2.42
|
3.45
|
0
|
N6
|
3.23
|
0
|
7.81*
|
3.33
|
6.45*
|
3.13
|
3.85
|
0
|
0
|
2.34
|
0
|
0
|
Control (H)
|
0
|
0
|
0.78
|
0
|
0
|
0
|
1.56
|
0
|
0
|
0
|
0
|
0
|
H1
|
6.25
|
3.91
|
6.25
|
3.70
|
3.33
|
0
|
0.78
|
0
|
0
|
3.91
|
7.81*
|
3.13
|
H2
|
4.84
|
5.47
|
0
|
4.17
|
5.56
|
2.78
|
20.24*
|
0
|
8.33*
|
2.34
|
1.61
|
0.78
|
H3
|
2.42
|
13.79
|
21.0
|
0
|
0.83
|
0
|
0
|
0
|
0.81
|
2.50
|
3.45
|
9.17*
|
H4
|
0.81
|
0.78
|
0
|
0
|
0
|
0
|
0
|
2.34
|
10.94*
|
5.47
|
1.61
|
4.69
|
Control (U)
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1.56
|
0
|
0
|
0
|
0
|
U1
|
3.70
|
1.61
|
3.13
|
0
|
0.93
|
0
|
0
|
0
|
0
|
0.78
|
4.69
|
0.81
|
U2
|
0
|
0
|
0.78
|
0
|
0
|
0.83
|
4.84
|
3.57
|
6.67
|
3.23
|
1.56
|
0.78
|
U3
|
15.74*
|
4.63
|
1.56
|
10.42*
|
1.61
|
4.31
|
2.50
|
0
|
0
|
3.91
|
6.25
|
3.13
|
U4
|
1.56
|
2.42
|
2.34
|
0.89
|
0
|
0.93
|
2.34
|
0
|
0
|
2.34
|
2.34
|
3.13
|
|
March 17
|
June 17
|
September 17
|
---|
Control (N)
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
N1
|
2.08
|
0
|
0
|
2.17
|
0
|
2.08
|
0
|
0
|
0
|
N2.1
|
0
|
0
|
0
|
3.13
|
1.04
|
6.52
|
0
|
0
|
0
|
N2.2
|
0
|
0
|
0
|
1.04
|
3.13
|
0
|
0
|
0
|
1.14
|
N2.3
|
0
|
0
|
0
|
5.21
|
4.17
|
2.08
|
0
|
1.09
|
7.14*
|
N2.4
|
1.04
|
0
|
0
|
0
|
2.08
|
0
|
1.25
|
0
|
0
|
Control (H2)
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
H1
|
1.09
|
3.13
|
0
|
6.25
|
0
|
0
|
2.38
|
1.04
|
0
|
H2
|
0
|
1.04
|
1.04
|
0
|
0
|
0
|
0
|
0
|
3.13
|
H2-DE
|
2.34
|
0
|
1.04
|
0
|
0
|
0
|
1.04
|
3.13
|
2.08
|
H2-F
|
1.56
|
9.78*
|
1.04
|
13.54*
|
4.17
|
5.43
|
0
|
7.61
|
0
|
H2-B
|
21.09*
|
25.00*
|
20.83*
|
16.30*
|
14.58*
|
23.96*
|
4.17
|
3.26
|
1.04
|
H2.1
|
2.08
|
0
|
3.13
|
2.27
|
0
|
3.13
|
0
|
1.09
|
0
|
H2.2
|
5.21
|
1.09
|
7.29
|
2.08
|
0
|
0
|
0
|
0
|
1.0
|
H2.3
|
8.33*
|
4.17
|
1.04
|
0
|
0
|
2.08
|
0
|
1.04
|
0
|
Control (H2a)
|
0
|
0
|
0
|
0
|
0
|
0
|
1.47
|
0
|
1.32
|
H2a oh
|
3.13
|
0
|
0
|
3.57
|
3.13
|
5.43
|
2.63
|
0
|
0
|
H2a-DE
|
0.78
|
1.04
|
0
|
0
|
4.17
|
1.04
|
1.19
|
0
|
0
|
H2a uh1
|
3.13
|
0
|
0
|
4.17
|
5.21
|
3.13
|
0
|
25.00*
|
0
|
H2a uh2
|
11.96*
|
3.13
|
1.04
|
0
|
0
|
0
|
7.81
|
0
|
13.75*
|
H2a uh3
|
1.09
|
9.38*
|
0
|
4.17
|
0
|
0
|
0
|
21.25*
|
2.38
|
H2a uh4
|
0
|
1.04
|
0
|
0
|
0
|
0
|
0
|
18.75*
|
0
|
- * Significant differences to control treatments; likelihood ratio χ2, Fisher’s exact test (p < 0.05), correction with sequential Bonferroni–Holm method p < α