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Table 4 Calculation of the predicted EC50 for a product considering only the a.s. at their maximum allowed concentrations (nominal concentrations) and calculation of the observed and predicted EC50 values considering concentrations of the a.s. measured at three concentration levels in a fish embryo test at test start (initial concentrations)

From: Environmental risk assessment of biocidal products: identification of relevant components and reliability of a component-based mixture assessment

Parameter IPBC Propiconazole Product
EC50 from regulatory source 0.067 mg l−1 4.3 mg l−1 n.a.
EC50 observed in the present study n.a. n.a. 96.1 mg product/l
Maximum allowed concentration in the product according to label 3960.4 mg l−1 7920.8 mg l−1 n.a.
Nominal proportion (P i ) in the product, based on maximum allowed concentration 0.3333 0.6667 n.a.
EC50 observed in the present study, based on nominal proportions n.a. n.a. 1.142 mg sum of IPBC and propiconazole/l
EC50 predicted by CA, based on nominal proportions n.a. n.a. 0.195 mg sum of IPBC and propiconazole/l
MDR, nominal n.a. n.a. 0.17
Recovery (initial measured in percent of nominal concentration), averaged over three concentration levels 91.4% 84.6% n.a.
Corrected concentration in product, based on initial measured concentrations in test 3620 mg l−1 6701 mg l−1 n.a.
Corrected P i in the product, based on corrected concentrations in the product 0.3507 0.6493 n.a.
EC50 observed in the present study, based on corrected P i n.a. n.a. 0.992 mg sum of IPBC and propiconazole l−1
EC50 predicted by CA, based on corrected P i n.a. n.a. 0.186 mg sum of IPBC and propiconazole l−1
MDR, corrected for initial measured concentrations n.a. n.a. 0.19
  1. The calculation in each row is based on the information provided in the rows above, using equations 1, 2, 4, 5, and 6
  2. n.a. not available/not applicable