Fig. 1

Wide-scale transcriptome profiles in liver and kidneys of NK603-fed rats. Liver and kidneys from control rats and animals fed NK603 GM maize either with or without Roundup application during the cultivation cycle were subjected to a full microarray transcriptome analysis. a PCA analysis of transcript cluster expression profiles shows no distinct separation into groups of treated (orange and green) and control (red) rats in both kidney and liver samples. By comparison, rats administered with Roundup (blue) in drinking water from the same experiment and subjected to the same transcriptome analysis clearly separate from the control and NK603 maize-fed groups. Each sphere represents the result of a single animal. b Volcano plots of the liver and kidney transcriptome profiles. Transcript cluster expression derived from the transcriptome profile data of liver and kidneys of control and NK603 maize-fed groups, either with or without Roundup (R) application, was plotted as log 2 fold change against −log10 p values. Each dot represents a single transcript cluster