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Table 10 Effect concentrations (EC10, EC50 with 95 % confidence interval) and NOEC, in mg/kg soil dry mass) for biomass production of B. napus and P. vulgaris of tylosin tartrate spiked via differently treated manure

From: Results of extended plant tests using more realistic exposure scenarios for improving environmental risk assessment of veterinary pharmaceuticals

Manure Species/endpoint Standard test (no manure) Fresh spiked 1/2 max incubation time Max. incubation time
  B. napus     
Cattle NOEC 48.1 25 156 156
EC10 35.2 36.7 254 78.7
(34.8–35.5) (25.2–44.9) (n.d.) (n.d.)
F   1.0 7.2 2.2
EC50 61.9 78.7* 326 351
(61.7–62.2) (69.2–90.3) (n.d.) (n.d.)
F   1.3 5.3 5.7
Valid No (60 % emerged) Yes Yes Yes
Pig NOEC 48.1 62.5 156 ≥391
EC10 35.2 101 n.d. n.d.
(34.8–35.5) (n.d.) (–) (–)
F   3 n.d. n.d.
EC50 61.9 131 n.d. n.d.
(61.7–62.2) (n.d.) (–) (–)
F   2.1 n.d. n.d.
valid No (60 % emerged) Yes Yes Yes
  P. vulgaris     
Cattle NOEC ≥800 40 194 194
EC10 9.1 25.3 175 202*
(3.0–17.4) (1.1–59.9) (n.d.) (33.6–315)
F   2.8 19 22
EC50 107 177 370 525*
(79.4–137) (88–346) (n.d.) (352–819)
F   1.7 3.5 4.9
valid No (58 % emerged) Yes Yes Yes
Pig NOEC ≥800 40 426 426
EC10 9.1 18.1 581 553
(3.0–17.4) (1.1–43.6) (n.d.) (n.d.)
F   2.0 64 61
EC50 107 142 837 885
(79.4–137) (72.5–253) (n.d.) (n.d.)
F   1.3 8 8
Valid No (58 % emerged) Yes Yes Yes
  1. Concentration range (B. napus): 16.0–144 and 50–800 mg/kg soil (standard test), 15.0–300 mg/kg soil (fresh spiked), 5.0–391 mg/kg soil (other tests); concentration range (P. vulgaris): 50–800 mg/kg soil (standard test), 40–937 mg/kg soil (other tests). Results evaluated as  % inhibition compared to the standard control (in standard tests) or the manure control (in extended tests)
  2. F factor of difference, ECx (manure spiked test)/ECx (standard test)
  3. * Significantly greater than value from standard test (based on overlapping 95 % confidence intervals)