Skip to main content

Table 10 Effect concentrations (EC10, EC50 with 95 % confidence interval) and NOEC, in mg/kg soil dry mass) for biomass production of B. napus and P. vulgaris of tylosin tartrate spiked via differently treated manure

From: Results of extended plant tests using more realistic exposure scenarios for improving environmental risk assessment of veterinary pharmaceuticals

Manure

Species/endpoint

Standard test (no manure)

Fresh spiked

1/2 max incubation time

Max. incubation time

 

B. napus

    

Cattle

NOEC

48.1

25

156

156

EC10

35.2

36.7

254

78.7

(34.8–35.5)

(25.2–44.9)

(n.d.)

(n.d.)

F

 

1.0

7.2

2.2

EC50

61.9

78.7*

326

351

(61.7–62.2)

(69.2–90.3)

(n.d.)

(n.d.)

F

 

1.3

5.3

5.7

Valid

No (60 % emerged)

Yes

Yes

Yes

Pig

NOEC

48.1

62.5

156

≥391

EC10

35.2

101

n.d.

n.d.

(34.8–35.5)

(n.d.)

(–)

(–)

F

 

3

n.d.

n.d.

EC50

61.9

131

n.d.

n.d.

(61.7–62.2)

(n.d.)

(–)

(–)

F

 

2.1

n.d.

n.d.

valid

No (60 % emerged)

Yes

Yes

Yes

 

P. vulgaris

    

Cattle

NOEC

≥800

40

194

194

EC10

9.1

25.3

175

202*

(3.0–17.4)

(1.1–59.9)

(n.d.)

(33.6–315)

F

 

2.8

19

22

EC50

107

177

370

525*

(79.4–137)

(88–346)

(n.d.)

(352–819)

F

 

1.7

3.5

4.9

valid

No (58 % emerged)

Yes

Yes

Yes

Pig

NOEC

≥800

40

426

426

EC10

9.1

18.1

581

553

(3.0–17.4)

(1.1–43.6)

(n.d.)

(n.d.)

F

 

2.0

64

61

EC50

107

142

837

885

(79.4–137)

(72.5–253)

(n.d.)

(n.d.)

F

 

1.3

8

8

Valid

No (58 % emerged)

Yes

Yes

Yes

  1. Concentration range (B. napus): 16.0–144 and 50–800 mg/kg soil (standard test), 15.0–300 mg/kg soil (fresh spiked), 5.0–391 mg/kg soil (other tests); concentration range (P. vulgaris): 50–800 mg/kg soil (standard test), 40–937 mg/kg soil (other tests). Results evaluated as  % inhibition compared to the standard control (in standard tests) or the manure control (in extended tests)
  2. F factor of difference, ECx (manure spiked test)/ECx (standard test)
  3. * Significantly greater than value from standard test (based on overlapping 95 % confidence intervals)