Fig. 1
From: Optimal test design for binary response data: the example of the fish embryo toxicity test
Sample size calculation. Logistic distribution of a concentration-response relationship (line) with a confidence interval (dotted lines around). a Difference between SL and TR xx at the dose-response curve (green arrow) marks the basic distance for calculation of the sample size. The confidence interval of SL is not shown. b Calculation of the sample size with the two different distributions of SL (light grey line) and a treated group (dark grey line). Under the restrictions of alpha and beta (red marked areas) will the optimal number of individuals be estimated (green line). IY immunity, SL spontaneous lethality, TR total risk, xx target value