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Table 4 Classifications of natural substances from the INCI list [8] according to the C&L inventory [13]

From: Naturally toxic: natural substances used in personal care products

(1) (2) (3)
H225 Highly flammable liquid and vapor 39 Acacia catechu (747), Pyrus malus extract (747)
H226 Flammable liquid and vapor 223 Allium sativum extract (747), Pinus pinaster extract (501)
H300 Fatal if swallowed 0 -
H301 Toxic if swallowed 9 Allium sativum extract (747), Artemisia absinthium extract (500), Tanacetum vulgare extract (128)
H302 Harmful if swallowed 36 Prunus amygdalus amara extract (847), Prunus amygdalus amara oil (22), Sassafras officinale extract (27), Viola odorata extract (746)
H304 May be fatal if swallowed and enters airways 130 Pelargonium graveolens oil (814), Picea excelsa extract (500), Pinus sylvestris leaf extract (502)
H310 Fatal in contact with skin 1 Nicotiana tabacum extract (27)
H311 Toxic in contact with skin 3 Brassica nigra extract (28), Chenopodium ambrosioides extract (69), Piper methysticum extract (7)
H312 Harmful in contact with skin 7 Cinnamomum cassia extract (834), Cinnamomum zeylandicum extract (247), Prunus amygdalus amara oil (23)
H314 Causes severe skin burns and eye damage (skin corrosive) 4 Origanum majorana extract (747), Satureia hortensis extract (748), Thymus serpillum extract (129), Thymus vulgaris extract (750)
H315 Causes skin irritation 137 Chamomilla recutita extract (772), Citrus aurantium dulcis oil (109)
H317 May cause an allergic skin reaction 198 Citrus medica limonum oil (127), Valeriana officinalis extract (502)
H318 Causes serious eye damage 17 Melissa officinalis extract (128), Rosa centifolia oil (89)
H319 Causes serious eye irritation 58 Rosa centifolia water (69), Valeriana officinalis extract (502)
H330 Fatal if inhaled 2 Brassica nigra extract (28), Tropaeolum majus extract (13)
H331 Toxic if inhaled 1 Piper methysticum extract (7)
H332 Harmful if inhaled 4 Artemisia vulgaris extract (128), Piper methysticum extract (7), Polianthes tuberosa extract (748), Prunus amygdalus amara oil (23)
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 3 pollen extract (1), Tabebuia impetiginosa bark extract (1), Tabebuia impetiginosa leaf extract (1)
H335 May cause respiratory irritation 8 Carum petroselinum seed oil (23), Quillaia saponaria extract (783)
H336 May cause drowsiness and dizziness 0 -
H340 May cause genetic defects 0 -
H341 Suspected of causing genetic defects 24 Artemisia dracunculus extract (748), Illicium verum oil (748)
H350 May cause cancer 4 Cinnamomum ceylandicum extract (500), Myristica fragrans extract (500), Myristica fragrans oil (61), Sassafras officinale extract (27)
H351 Suspected of causing cancer 23 Artemisia dracunculus extract (748), Crocus sativus extract (58), Cymbopogon nardus oil (747), Foeniculum vulgare extract (500), Illicium verum oil (747), Laurus nobilis extract (747), Levisticum officinale extract (749), Ocimum basilicum extract (500), Pimpinella anisum extract (747), Rosa damascena distillate (748)
H360 May damage fertility or the unborn child 1 Urtica urens extract (747)
H361 Suspected of damaging fertility or the unborn child 1 Melia azadirachta seed oil (1)
H362 May cause harm to breast-fed children 0 -
H370 Causes damage to organs 0 -
H371 May cause damage to organs 6 Artemisia vulgaris extract (128), Foeniculum vulgare oil (65), Laurus nobilis oil (64), Lawsonia inermis extract (1), Ocimum basilicum oil (84), Rosmarinus officinalis oil (89)
H373 May cause damage to organs through prolonged or repeated exposure 5 Artemisia absinthium extract (500), Lavandula hybrida extract (748), Rosmarinus officinalis extract (748), Salvia officinalis extract (500), Salvia officinalis water (500)
H400 Very toxic to aquatic life 74 Apium graveolens extract (501), Valeriana officinalis extract (502)
H410 Very toxic to aquatic life with long lasting effects 77 Carum carvi extract (504), Citrus grandis peel extract (575)
H411 Toxic to aquatic life with long lasting effects 63 Coriandrum sativum extract (766), Daucus carota extract (747)
H412 Harmful to aquatic life with long lasting effects 41 Humulus lupulus extract (747), Illicium verum oil (747)
H413 May cause long lasting harmful effects to aquatic life 5 Origanum vulgare extract (67), Thymus vulgaris oil (66), Tropaeolum majus extract (13)
  1. Column (1) are the substance names in the INCI list.
  2. Column (2) are the CAS and EC numbers in the INCI list or in the REACH registrations and the production tonnage bands as given in the REACH registrations.
  3. Column (3) are the H-phrases given by the clear majority in the C&L inventory with the number of notifiers in brackets and the H-phrases as given in the REACH registration dossier. The number of notifiers in the C&L inventory which classify a substances in the same way as in the REACH dossier is also listed.