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Table 4 Classifications of natural substances from the INCI list [8] according to the C&L inventory [13]

From: Naturally toxic: natural substances used in personal care products

(1)

(2)

(3)

H225

Highly flammable liquid and vapor

39

Acacia catechu (747), Pyrus malus extract (747)

H226

Flammable liquid and vapor

223

Allium sativum extract (747), Pinus pinaster extract (501)

H300

Fatal if swallowed

0

-

H301

Toxic if swallowed

9

Allium sativum extract (747), Artemisia absinthium extract (500), Tanacetum vulgare extract (128)

H302

Harmful if swallowed

36

Prunus amygdalus amara extract (847), Prunus amygdalus amara oil (22), Sassafras officinale extract (27), Viola odorata extract (746)

H304

May be fatal if swallowed and enters airways

130

Pelargonium graveolens oil (814), Picea excelsa extract (500), Pinus sylvestris leaf extract (502)

H310

Fatal in contact with skin

1

Nicotiana tabacum extract (27)

H311

Toxic in contact with skin

3

Brassica nigra extract (28), Chenopodium ambrosioides extract (69), Piper methysticum extract (7)

H312

Harmful in contact with skin

7

Cinnamomum cassia extract (834), Cinnamomum zeylandicum extract (247), Prunus amygdalus amara oil (23)

H314

Causes severe skin burns and eye damage (skin corrosive)

4

Origanum majorana extract (747), Satureia hortensis extract (748), Thymus serpillum extract (129), Thymus vulgaris extract (750)

H315

Causes skin irritation

137

Chamomilla recutita extract (772), Citrus aurantium dulcis oil (109)

H317

May cause an allergic skin reaction

198

Citrus medica limonum oil (127), Valeriana officinalis extract (502)

H318

Causes serious eye damage

17

Melissa officinalis extract (128), Rosa centifolia oil (89)

H319

Causes serious eye irritation

58

Rosa centifolia water (69), Valeriana officinalis extract (502)

H330

Fatal if inhaled

2

Brassica nigra extract (28), Tropaeolum majus extract (13)

H331

Toxic if inhaled

1

Piper methysticum extract (7)

H332

Harmful if inhaled

4

Artemisia vulgaris extract (128), Piper methysticum extract (7), Polianthes tuberosa extract (748), Prunus amygdalus amara oil (23)

H334

May cause allergy or asthma symptoms or breathing difficulties if inhaled

3

pollen extract (1), Tabebuia impetiginosa bark extract (1), Tabebuia impetiginosa leaf extract (1)

H335

May cause respiratory irritation

8

Carum petroselinum seed oil (23), Quillaia saponaria extract (783)

H336

May cause drowsiness and dizziness

0

-

H340

May cause genetic defects

0

-

H341

Suspected of causing genetic defects

24

Artemisia dracunculus extract (748), Illicium verum oil (748)

H350

May cause cancer

4

Cinnamomum ceylandicum extract (500), Myristica fragrans extract (500), Myristica fragrans oil (61), Sassafras officinale extract (27)

H351

Suspected of causing cancer

23

Artemisia dracunculus extract (748), Crocus sativus extract (58), Cymbopogon nardus oil (747), Foeniculum vulgare extract (500), Illicium verum oil (747), Laurus nobilis extract (747), Levisticum officinale extract (749), Ocimum basilicum extract (500), Pimpinella anisum extract (747), Rosa damascena distillate (748)

H360

May damage fertility or the unborn child

1

Urtica urens extract (747)

H361

Suspected of damaging fertility or the unborn child

1

Melia azadirachta seed oil (1)

H362

May cause harm to breast-fed children

0

-

H370

Causes damage to organs

0

-

H371

May cause damage to organs

6

Artemisia vulgaris extract (128), Foeniculum vulgare oil (65), Laurus nobilis oil (64), Lawsonia inermis extract (1), Ocimum basilicum oil (84), Rosmarinus officinalis oil (89)

H373

May cause damage to organs through prolonged or repeated exposure

5

Artemisia absinthium extract (500), Lavandula hybrida extract (748), Rosmarinus officinalis extract (748), Salvia officinalis extract (500), Salvia officinalis water (500)

H400

Very toxic to aquatic life

74

Apium graveolens extract (501), Valeriana officinalis extract (502)

H410

Very toxic to aquatic life with long lasting effects

77

Carum carvi extract (504), Citrus grandis peel extract (575)

H411

Toxic to aquatic life with long lasting effects

63

Coriandrum sativum extract (766), Daucus carota extract (747)

H412

Harmful to aquatic life with long lasting effects

41

Humulus lupulus extract (747), Illicium verum oil (747)

H413

May cause long lasting harmful effects to aquatic life

5

Origanum vulgare extract (67), Thymus vulgaris oil (66), Tropaeolum majus extract (13)

  1. Column (1) are the substance names in the INCI list.
  2. Column (2) are the CAS and EC numbers in the INCI list or in the REACH registrations and the production tonnage bands as given in the REACH registrations.
  3. Column (3) are the H-phrases given by the clear majority in the C&L inventory with the number of notifiers in brackets and the H-phrases as given in the REACH registration dossier. The number of notifiers in the C&L inventory which classify a substances in the same way as in the REACH dossier is also listed.