Figure 3

Orthogonal partial least squares-discriminant analysis (OPLS-DA) forbiochemical data (females fed 33% GMO versus controls). (A) First,detailed examples of significant discriminant variables distribution betweenfemales fed 33% GMO (bold line) and controls (dotted line). On X axis,animals; on Y axis, serum or urine biochemical values for Na, Cl,estradiol, testosterone. (B) Wider view of OPLS-DA regressioncoefficients for predictive component, with jack-knifed confidence intervals at99% confidence level, indicating discriminant parameters versus controls atmonth 15. U, urinary; UEx, excreted in urine during 24 h; APPT, activatedpartial thromboplastin time; MCV, mean corpuscular volume; PT, prothrombinetime; RBC, red blood cells; ALT, alanine aminotransferase; MCHC, meancorpuscular hemoglobin concentration; A/G, albumin/globulin ratio; WBC, whiteblood cells; AST, aspartate aminotransferase. Profiles evidence kidney ionleakages and sex hormonal imbalance versus controls.