Proposal for a harmonised PBT identification across different regulatory frameworks

Environmental Sciences Europe

Table 6 Main elements of our proposal for a harmonized assessment of toxicity across regulatory frameworks

	Toxicity
	Definitive assessment	Screening assessment
Criteria	NOEC (long-term) < 0.01 mg/L, marine or freshwater species	≥1 value for acute LC₅₀/EC₅₀ < 0.1 mg/L: potentially toxic
	CMR substances	Acute LC₅₀/EC₅₀ values < 0.01 mg/L: toxic
	Other evidence of chronic toxicity	Acute LC₅₀/EC₅₀ values < 0.01 mg/L: toxic
Proposal	Other information to consider	Other information to consider
	NOEC ≤ 30 mg/kg food, birds and mammals	QSAR
	Long-term tests on terrestrial organisms	Read-across from structurally related substances.
	High log K_OW: sediment-dwelling species tests
	Information from non-standard aquatic studies and endpoints
	Endocrine-disrupting potential