Table 5 Main elements of our proposal for a harmonized assessment of bioaccumulation across the regulatory frameworks
From: Proposal for a harmonised PBT identification across different regulatory frameworks
Bioaccumulation | ||
|---|---|---|
Definitive assessment | Screening assessment | |
Criteria | BCF > 2,000 L/kg (>5,000 L/kg) | Log KOW > 4.5 |
Proposal | BCF (normalised to 5% lipid content) | QSAR if log KOW is between 4.5 and 6, log KOW > 6: expert judgement, case- by-case |
For high log KOW and poorly soluble or non-soluble: consider BAF, BMF (BMF > 1 indicative) | Other information to consider | |
Other information to consider | Surface-activity | |
High bioaccumulation in species other than fish | Structural alerts | |
Different uptake routes | High log KOA for air-breathing organisms | |
Accumulation in specific tissues | Read-across from structurally related substances. | |
Non-lipid based accumulation | ||
Toxicokinetic and chronic studies with mammals | ||
In vitro data on aquatic bioaccumulation | ||