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Table 1 Compliance with the EFSA requirements by the three studies

From: Rat feeding studies with genetically modified maize - a comparative evaluation of applied methods and risk assessment standards

Requirement Level of compliance
Séralini et al.[3] Hammond et al.[14] Monsanto[12]
Study objectives need to be clearly stated a priori in the study protocol Medium Medium Medium
Suitable controls for all treatment groups need to be presented No data shown (high)a High High
Biological relevance of the rat strain used should be justified Low Low Low
Measures taken to reduce the risk of bias (e.g. blinding) need to be taken No data shown (high)a No data shown No data shown
Critical information about the diet composition need to be reported No data shown No data shown High
Details of the storage conditions of the feed need to be provided No data shown No data shown No data shown
Contamination of the diets, e.g. by mycotoxins, pesticides etc., need to be reported No data shown (medium)a No data shown High
All collected endpoints should be reported openly and transparently No data shown Medium High
The presented data need to ensure the calculation of exposure to the test substance No data shown No data shown Medium
The sample size (power) calculation must be presented, especially when the study objectives are unclear Low Low Low
(but reference to OECD GL408) (but reference to OECD GL408)
  1. Based on EFSA [8] and EFSA Scientific Committee [9]. aCompliance level is enclosed in brackets based on additional information given by Séralini et al. [15].