Study objectives need to be clearly stated a priori in the study protocol
|
Medium
|
Medium
|
Medium
|
Suitable controls for all treatment groups need to be presented
|
No data shown (high)a
|
High
|
High
|
Biological relevance of the rat strain used should be justified
|
Low
|
Low
|
Low
|
Measures taken to reduce the risk of bias (e.g. blinding) need to be taken
|
No data shown (high)a
|
No data shown
|
No data shown
|
Critical information about the diet composition need to be reported
|
No data shown
|
No data shown
|
High
|
Details of the storage conditions of the feed need to be provided
|
No data shown
|
No data shown
|
No data shown
|
Contamination of the diets, e.g. by mycotoxins, pesticides etc., need to be reported
|
No data shown (medium)a
|
No data shown
|
High
|
All collected endpoints should be reported openly and transparently
|
No data shown
|
Medium
|
High
|
The presented data need to ensure the calculation of exposure to the test substance
|
No data shown
|
No data shown
|
Medium
|
The sample size (power) calculation must be presented, especially when the study objectives are unclear
|
Low
|
Low
|
Low
|
(but reference to OECD GL408)
|
(but reference to OECD GL408)
|